Microbial alkaline serine proteases: Production, properties and applications

Proteolytic enzymes hold a pivotal position in numerous industrial processes where hydrolysis of protein molecules is required under precise conditions. The emerging trend of biotechnological applications in recent years has witnessed a renewed interest in alkaline serine proteases extending their utility in detergent, leather, textile, food and pharmaceutical industries. A variety of microorganisms have been reported to produce alkaline serine proteases on a large scale, however, extensive research to find an alkaline serine protease with desirable characteristics such as significant catalytic efficiency, expanded stability and broad substrate specificity is still ongoing. Although submerged fermentation dominates the commercial enzyme production, recent reports have emphasized on solid state fermentation technology which can reduce major cost associated with the enzyme production. In the present review, recent research on alkaline serine proteases along with their novel properties and production using solid state fermentation have been discussed.

Automated summary

Proteolytic enzymes play a crucial role in various industrial processes, especially in protein hydrolysis. The recent trend of biotechnological applications has sparked renewed interest in alkaline serine proteases, expanding their applications in different industries. While many microorganisms have been found to produce alkaline serine proteases on a large scale, research is still ongoing to find enzymes with desirable characteristics.