Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 27, Issue 17, Pages 1943-1958Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v27.i17.1943
Keywords
Pancreatic cancer; Systemic therapy; Platinum chemotherapy; BRCA; Deoxyribonucleic acid repair; Poly (ADP-ribose) polymerase inhibitors
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Pancreatic cancer is a deadly disease, especially for patients with BRCA mutations. These mutation carriers have some effective treatment options, including platinum-based chemotherapy and poly (ADP-ribose) polymerase inhibitors.
Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced disease. Recently, patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast tumors. Germline BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8% of patients with sporadic pancreatic cancer. In patients with germline BRCA mutations, platinum-based chemotherapies and poly (ADP-ribose) polymerase inhibitors are effective treatment options which may offer survival benefits. This review will focus on the molecular biology, epidemiology, and management of BRCA-mutated pancreatic cancer. Furthermore, we will discuss future directions for this area of research and promising active areas of research.
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