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A new NIR-triggered doxorubicin and photosensitizer indocyanine green co-delivery system for enhanced multidrug resistant cancer treatment through simultaneous chemo/photothermal/photodynamic therapy
Yanna Yu et al.
ACTA BIOMATERIALIA (2017)
A chemo/photo- co-therapeutic system for enhanced multidrug resistant cancer treatment using multifunctional mesoporous carbon nanoparticles coated with poly (curcumin-dithiodipropionic acid)
Fangzhou Li et al.
CARBON (2017)
Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells
Ruili Zhang et al.
ADVANCED FUNCTIONAL MATERIALS (2017)
Dual Stimuli-Responsive Nanoparticles for Controlled Release of Anticancer and Anti-inflammatory Drugs Combination
Liandong Feng et al.
CHEMISTRY-A EUROPEAN JOURNAL (2017)
Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
Rama Rathore et al.
APOPTOSIS (2017)
Rational Design of Metal Organic Framework Nanocarrier-Based Codelivery System of Doxorubicin Hydrochloride/Verapamil Hydrochloride for Overcoming Multidrug Resistance with Efficient Targeted Cancer Therapy
Huiyuan Zhang et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
P-gp Inhibition and Mitochondrial Impairment by Dual-Functional Nanostructure Based on Vitamin E Derivatives To Overcome Multidrug Resistance
Ruslan G. Tuguntaev et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
MnO2-Based Nanoplatform Serves as Drug Vehicle and MRI Contrast Agent for Cancer Theranostics
Mei Zhang et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Nanocarriers for microRNA delivery in cancer medicine
I. Fernandez-Pineiro et al.
BIOTECHNOLOGY ADVANCES (2017)
Shape-Dependent Radiosensitization Effect of Gold Nanostructures in Cancer Radiotherapy: Comparison of Gold Nanoparticles, Nanospikes, and Nanorods
Ningning Ma et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Near-Infrared Laser-Triggered Nitric Oxide Nanogenerators for the Reversal of Multidrug Resistance in Cancer
Ranran Guo et al.
ADVANCED FUNCTIONAL MATERIALS (2017)
Facial Layer-by-Layer Engineering of Upconversion Nanoparticles for Gene Delivery: Near-Infrared-Initiated Fluorescence Resonance Energy Transfer Tracking and Overcoming Drug Resistance in Ovarian Cancer
Min Lin et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Se/Ru-Decorated Porous Metal-Organic Framework Nanoparticles for The Delivery of Pooled siRNAs to Reversing Multidrug Resistance in Taxol-Resistant Breast Cancer Cells
Qingchang Chen et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Systematic evaluation of multifunctional paclitaxel-loaded polymeric mixed micelles as a potential anticancer remedy to overcome multidrug resistance
Jiulong Zhang et al.
ACTA BIOMATERIALIA (2017)
Combinatorial Approach to Nanoarchitectonics for Nonviral Delivery of Nucleic Acids
Mijanur Rahaman Molla et al.
ADVANCED MATERIALS (2016)
Tumor-Homing and Penetrating Peptide-Functionalized Photosensitizer-Conjugated PEG-PLA Nanoparticles for Chemo-Photodynamic Combination Therapy of Drug-Resistant Cancer
Xingye Feng et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
Enhanced Radiosensitization of Gold Nanospikes via Hyperthermia in Combined Cancer Radiation and Photothermal Therapy
Ningning Ma et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
Light-Responsive Biodegradable Nanomedicine Overcomes Multidrug Resistance via NO-Enhanced Chemosensitization
Jing Fan et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor
Tingting Wang et al.
ACS NANO (2016)
Controllable CO Release Following Near Infrared Light-Induced Cleavage of Iron Carbonyl Derivatized Prussian Blue Nanoparticles for CO-Assisted Synergistic Treatment
Wei-Peng Li et al.
ACS NANO (2016)
Co-delivery of Se nanoparticles and pooled SiRNAs for overcoming drug resistance mediated by P-glycoprotein and class III β-tubulin in drug-resistant breast cancers
Wenjing Zheng et al.
ACTA BIOMATERIALIA (2016)
Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy
Kai Yang et al.
ADVANCED DRUG DELIVERY REVIEWS (2016)
Recent progress in development of siRNA delivery vehicles for cancer therapy
Hyun Jin Kim et al.
ADVANCED DRUG DELIVERY REVIEWS (2016)
Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer
Jong-Lyel Roh et al.
CANCER LETTERS (2016)
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
Zhaolin Chen et al.
CANCER LETTERS (2016)
A safe, simple and efficient doxorubicin prodrug hybrid micelle for overcoming tumor multidrug resistance and targeting delivery
Yuling Bao et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy
Shengpeng Wang et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Nanoscale Coordination Polymers Codeliver Chemotherapeutics and siRNAs to Eradicate Tumors of Cisplatin-Resistant Ovarian Cancer
Chunbai He et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Doxorubicin and siRNA Codelivery via Chitosan-Coated pH-Responsive Mixed Micellar Polyplexes for Enhanced Cancer Therapy in Multidrug-Resistant Tumors
Adeel Masood Butt et al.
MOLECULAR PHARMACEUTICS (2016)
Osimertinib (AZD9291) Attenuates the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCB1 in Vitro
Sung-Han Hsiao et al.
MOLECULAR PHARMACEUTICS (2016)
Actively targeting D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) nanoparticles as vesicles for chemo-photodynamic combination therapy of doxorubicin-resistant breast cancer
Di Jiang et al.
NANOSCALE (2016)
Endogenous Sulfur Dioxide: A New Member of Gasotransmitter Family in the Cardiovascular System
Yaqian Huang et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Light-responsive AIE nanoparticles with cytosolic drug release to overcome drug resistance in cancer cells
Youyong Yuan et al.
POLYMER CHEMISTRY (2016)
A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS
Zhengze Yu et al.
CHEMICAL SCIENCE (2016)
Multi-Responsive Turn-On Nanocarriers for Efficient Site-Specific Gene Delivery In Vitro and In Vivo
Yiyan He et al.
ADVANCED HEALTHCARE MATERIALS (2016)
Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics
Gan Lin et al.
ADVANCED SCIENCE (2016)
Micelles of d-α-Tocopheryl Polyethylene Glycol 2000 Succinate (TPGS 2K) for Doxorubicin Delivery with Reversal of Multidrug Resistance
Tangna Hao et al.
ACS APPLIED MATERIALS & INTERFACES (2015)
Hybrid Lipid-Capped Mesoporous Silica for Stimuli-Responsive Drug Release and Overcoming Multidrug Resistance
Ning Han et al.
ACS APPLIED MATERIALS & INTERFACES (2015)
Multifunctional polyamidoamine-modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549/DDP cells for reversal multidrug resistance
Wenjing Zheng et al.
ACTA BIOMATERIALIA (2015)
pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer
Haijun Yu et al.
ADVANCED FUNCTIONAL MATERIALS (2015)
A pH-Responsive Carrier System that Generates NO Bubbles to Trigger Drug Release and Reverse P-Glycoprotein-Mediated Multidrug Resistance
Ming-Fan Chung et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Doxorubicin-loaded NaYF4:Yb/Tm-TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers
Leyong Zeng et al.
BIOMATERIALS (2015)
Self-assembled nanoscale coordination polymers carrying siRNAs and cisplatin for effective treatment of resistant ovarian cancer
Chunbai He et al.
BIOMATERIALS (2015)
A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic-chemotherapy against cisplatin resistant cancer cells
Youyong Yuan et al.
CHEMICAL COMMUNICATIONS (2015)
Nanoparticles in Photodynamic Therapy
Sasidharan Swarnalatha Lucky et al.
CHEMICAL REVIEWS (2015)
The role of ABC transporters in ovarian cancer progression and chemoresistance
M. P. Ween et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2015)
Lipid-Based Nanocarriers for RNA Delivery
Hui Yi Xue et al.
CURRENT PHARMACEUTICAL DESIGN (2015)
Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance
Ji Young Yhee et al.
JOURNAL OF CONTROLLED RELEASE (2015)
Enhance Cancer Cell Recognition and Overcome Drug Resistance Using Hyaluronic Acid and α-Tocopheryl Succinate Based Multifunctional Nanoparticles
Desheng Liang et al.
MOLECULAR PHARMACEUTICS (2015)
Overcoming Multiple Drug Resistance by Spatial-Temporal Synchronization of Epirubicin and Pooled siRNAs
Wei Chen et al.
SMALL (2015)
Liposomal siRNA nanocarriers for cancer therapy
Bulent Ozpolat et al.
ADVANCED DRUG DELIVERY REVIEWS (2014)
Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells
Zhongliang Wang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Hypoxia- Targeted siRNA Delivery
F. Perche et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation
Tip W. Loo et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Delivery of siRNA by MRI-visible nanovehicles to overcome drug resistance in MCF-7/ADR human breast cancer cells
Gan Lin et al.
BIOMATERIALS (2014)
Restoration of chemosensitivity by multifunctional micelles mediated by P-gp siRNA to reverse MDR
Jie Shen et al.
BIOMATERIALS (2014)
Low-density lipoprotein-coupled N-succinyl chitosan nanoparticles co-delivering siRNA and doxorubicin for hepatocyte-targeted therapy
Qiao-ling Zhu et al.
BIOMATERIALS (2014)
Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles
Li Li et al.
BIOMATERIALS (2014)
Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: A promising strategy to overcome drug resistance in cancer
G. Salzano et al.
CANCER LETTERS (2014)
Diversity in ABC transporters: Type I, II and III importers
Austin J. Rice et al.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)
ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi et al.
CURRENT PHARMACEUTICAL DESIGN (2014)
Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: Current progress and advances
Nishant S. Gandhi et al.
JOURNAL OF CONTROLLED RELEASE (2014)
Nanoscale Metal-Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells
Chunbai He et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Inorganic Nanoparticle-Based Drug Codelivery Nanosystems To Overcome the Multidrug Resistance of Cancer Cells
Yu Chen et al.
MOLECULAR PHARMACEUTICS (2014)
Combinational Delivery of Hydrophobic and Hydrophilic Anticancer Drugs in Single Nanoemulsions To Treat MDR in Cancer
Yan Ma et al.
MOLECULAR PHARMACEUTICS (2014)
Doxorubicin and Lapatinib Combination Nanomedicine for Treating Resistant Breast Cancer
Huiyuan Wang et al.
MOLECULAR PHARMACEUTICS (2014)
Pluronics and MDR Reversal: An Update
Daria Y. Alakhova et al.
MOLECULAR PHARMACEUTICS (2014)
Sulfur dioxide, a double-faced molecule in mammals
Xin-Bao Wang et al.
LIFE SCIENCES (2014)
Tyrosine Kinase Inhibitors as Reversal Agents for ABC Transporter Mediated Drug Resistance
Nagaraju Anreddy et al.
MOLECULES (2014)
Recent developments in the co-delivery of siRNA and small molecule anticancer drugs for cancer treatment
Manju Saraswathy et al.
MATERIALS TODAY (2014)
Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo
Huan Meng et al.
ACS NANO (2013)
Multidrug resistance: Physiological principles and nanomedical solutions
Sijumon Kunjachan et al.
ADVANCED DRUG DELIVERY REVIEWS (2013)
Nanotechnology approaches for personalized treatment of multidrug resistant cancers
Tamara Minko et al.
ADVANCED DRUG DELIVERY REVIEWS (2013)
Nanopreparations to overcome multidrug resistance in cancer
Niravkumar R. Patel et al.
ADVANCED DRUG DELIVERY REVIEWS (2013)
Gold Nanorod-Cored Biodegradable Micelles as a Robust and Remotely Controllable Doxorubicin Release System for Potent Inhibition of Drug-Sensitive and -Resistant Cancer Cells
Yinan Zhong et al.
BIOMACROMOLECULES (2013)
Reversing multidrug resistance by intracellular delivery of Pluronic® P85 unimers
Wei Hong et al.
BIOMATERIALS (2013)
Tumor targeting and microenvironment-responsive nanoparticles for gene delivery
Shixian Huang et al.
BIOMATERIALS (2013)
Nuclear localization of P-glycoprotein is responsible for protection of the nucleus from doxorubicin in the resistant LoVo cell line
Witold Szaflarski et al.
BIOMEDICINE & PHARMACOTHERAPY (2013)
Different strategies to overcome multidrug resistance in cancer
Manju Saraswathy et al.
BIOTECHNOLOGY ADVANCES (2013)
Vitamin E reverses multidrug resistance in vitro and in vivo
Jingling Tang et al.
CANCER LETTERS (2013)
Nanocarriers for siRNA delivery to overcome cancer multidrug resistance
Meng QingShuo et al.
CHINESE SCIENCE BULLETIN (2013)
In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles
Shanthi Ganesh et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Stimuli-responsive nanocarriers for drug delivery
Simona Mura et al.
NATURE MATERIALS (2013)
Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges
Ligia C. Gomes-da-Silva et al.
ACCOUNTS OF CHEMICAL RESEARCH (2012)
Nanoparticles in cancer therapy and diagnosis
Irene Brigger et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
RNAi-based nanomedicines for targeted personalized therapy
Ala Daka et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
A review of nanocarriers for the delivery of small interfering RNA
Prashant Kesharwani et al.
BIOMATERIALS (2012)
Multimodality treatment of cancer with herceptin conjugated, thermomagnetic iron oxides and docetaxel loaded nanoparticles of biodegradable polymers
Yu Mi et al.
BIOMATERIALS (2012)
Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors
Yuebin Shan et al.
BIOMATERIALS (2012)
Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors
Yongzhong Wang et al.
BIOMATERIALS (2012)
Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance
Suneet Shukla et al.
DRUG RESISTANCE UPDATES (2012)
Overcoming drug resistance of MCF-7/ADR cells by altering intracellular distribution of doxorubicin via MVP knockdown with a novel siRNA polyamidoamine-hyaluronic acid complex
Min Han et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Protein-based nanocarriers as promising drug and gene delivery systems
Ahmed O. Elzoghby et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance
Mar Creixell et al.
NANO TODAY (2012)
Novel Tubulin Polymerization Inhibitors Overcome Multidrug Resistance and Reduce Melanoma Lung Metastasis
Zhao Wang et al.
PHARMACEUTICAL RESEARCH (2012)
Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin
Xiao-Bing Xiong et al.
ACS NANO (2011)
Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcomes drug-resistance in vivo
Hsueh-Lin Lu et al.
JOURNAL OF CONTROLLED RELEASE (2011)
Coformulation of Doxorubicin and Curcumin in Poly(D,L-lactide-co-glycolide) Nanoparticles Suppresses the Development of Multidrug Resistance in K562 Cells
Ranjita Misra et al.
MOLECULAR PHARMACEUTICS (2011)
The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer Chemotherapy
Chung-Pu Wu et al.
MOLECULAR PHARMACEUTICS (2011)
Engineering Nanocarriers for siRNA Delivery
Shawn J. Tan et al.
SMALL (2011)
Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-Glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line
Huan Meng et al.
ACS NANO (2010)
Co-delivery of PDTC and doxorubicin by multifunctional micellar nanoparticles to achieve active targeted drug delivery and overcome multidrug resistance
Li Fan et al.
BIOMATERIALS (2010)
The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
Yogesh B. Patil et al.
BIOMATERIALS (2010)
Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers
Elena V. Batrakova et al.
JOURNAL OF CONTROLLED RELEASE (2010)
Differential metabolic responses to pluronic in MDR and non-MDR cells: A novel pathway for chemosensitization of drug resistant cancers
Daria Yu. Alakhova et al.
JOURNAL OF CONTROLLED RELEASE (2010)
Nano particle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance
Ayman Khdair et al.
JOURNAL OF CONTROLLED RELEASE (2010)
Vitamin E TPGS P-Glycoprotein Inhibition Mechanism: Influence on Conformational Flexibility, Intracellular ATP Levels, and Role of Time and Site of Access
Eva-Maria Collnot et al.
MOLECULAR PHARMACEUTICS (2010)
Emerging applications of stimuli-responsive polymer materials
Martien A. Cohen Stuart et al.
NATURE MATERIALS (2010)
The therapeutic potential of carbon monoxide
Roberto Motterlini et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug-Resistant Cancer Cells
Alex M. Chen et al.
SMALL (2009)
Targeting DNA topoisomerase II in cancer chemotherapy
John L. Nitiss
NATURE REVIEWS CANCER (2009)
Nanoparticles in photodynamic therapy: An emerging paradigm
Dev Kumar Chatterjee et al.
ADVANCED DRUG DELIVERY REVIEWS (2008)
An overview of cancer multidrug resistance: a still unsolved problem
H. Lage
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
A review of stimuli-responsive nanocarriers for drug and gene delivery
Srinivas Ganta et al.
JOURNAL OF CONTROLLED RELEASE (2008)
Drug resistance and the solid tumor microenvironment
Olivier Tredan et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)
The resurgence of platinum-based cancer chemotherapy
Lloyd Kelland
NATURE REVIEWS CANCER (2007)
Targeted nanoparticles for cancer therapy
Frank X. Gu et al.
NANO TODAY (2007)
Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling
Lisa J. Frederiksen et al.
CLINICAL CANCER RESEARCH (2007)
Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor
Elizabeth Fox et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2007)
Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization
Pei-Jen Lou et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2
Christopher A. McDevitt et al.
STRUCTURE (2006)
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Roger G. Deeley et al.
PHYSIOLOGICAL REVIEWS (2006)
Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
C Nakanishi et al.
NATURE REVIEWS CANCER (2005)
Timeline - Chemotherapy and the war on cancer
BA Chabner et al.
NATURE REVIEWS CANCER (2005)
DNA repair pathways in drug resistance in melanoma
PA Bradbury et al.
ANTI-CANCER DRUGS (2004)
Molecular targeting of drug delivery systems to cancer
T Minko et al.
CURRENT DRUG TARGETS (2004)
Pluronic® block copolymers for overcoming drug resistance in cancer
AV Kabanov et al.
ADVANCED DRUG DELIVERY REVIEWS (2002)
The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines
S Radetzki et al.
ONCOGENE (2002)
From bench to clinic with apoptosis-based therapeutic agents
DW Nicholson
NATURE (2000)