4.5 Article

The COVID-19 vaccine development: A pandemic paradigm

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies

Ivan Mercurio et al.

Summary: The recent COVID-19 pandemic has led to a global health emergency and calls for the scientific community to identify new tools for diagnosis and treatment. In silico analysis has provided insights into conformational changes of the SARS-CoV-2 spike protein and potential antibodies that could target it to prevent virus invasion into human cells. This analysis also offers guidance for developing new vaccines and treatments based on targeting the spike protein.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Infectious Diseases

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

Shengli Xia et al.

Summary: The inactivated SARS-CoV-2 vaccine, BBIBP-CorV, demonstrated safety and immunogenicity in two age groups. Humoral responses against SARS-CoV-2 were induced in all vaccine recipients by day 42. A two-dose immunisation with 4 mu g vaccine on days 0 and 21 or days 0 and 28 achieved higher neutralising antibody titres compared to other dosing schedules.

LANCET INFECTIOUS DISEASES (2021)

Review Pharmacology & Pharmacy

Nanocarrier vaccines for SARS-CoV-2

Jatin Machhi et al.

Summary: This article summarizes the treatment and vaccine development during the COVID-19 pandemic, focusing on the role played by nanocarrier delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

Review Pharmacology & Pharmacy

Non-viral COVID-19 vaccine delivery systems

Kyung Soo Park et al.

Summary: The novel coronavirus SARS-CoV-2 has rapidly spread worldwide, causing millions of cases and over a million deaths. Various types of vaccines, including traditional and advanced DNA and mRNA vaccines, are being developed. The efficacy and duration of protection of these vaccines depend on factors such as antigen design and delivery strategies, and further research is needed.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Allergy

Principles and Challenges in anti-COVID-19 Vaccine Development

Zuzana Strizova et al.

Summary: Despite rising cases of SARS-CoV-2 infection in European countries, prevention through vaccination is seen as the best hope for controlling the spread of the virus. Various types of vaccines, including viral vector-based, genetic, attenuated, and protein-based vaccines, are being tested in over 80 clinical trials with some reaching advanced stages.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2021)

Article Medicine, General & Internal

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Denis Y. Logunov et al.

Summary: The Gam-COVID-Vac vaccine showed 91.6% efficacy against COVID-19 in the phase 3 trial, with good safety and tolerability in a large cohort of participants.

LANCET (2021)

Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

Yanjun Zhang et al.

Summary: This study investigated the safety, tolerability, and immunogenicity of the COVID-19 vaccine candidate CoronaVac, and found that the 3 μg dose showed higher seroconversion rates in the phase 2 trial.

LANCET INFECTIOUS DISEASES (2021)

Article Public, Environmental & Occupational Health

The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Janssen COVID-19 Vaccine — United States, February 2021

Sara E. Oliver et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

Review Biochemical Research Methods

The Relevance of Bioinformatics Applications in the Discovery of Vaccine Candidates and Potential Drugs for COVID-19 Treatment

Onyeka S. Chukwudozie et al.

Summary: The application of bioinformatics in investigating the molecular characteristics of infectious pathogens, particularly in response to the novel coronavirus pandemic, has played a crucial role in accelerating the analysis of pathogens and drug development.

BIOINFORMATICS AND BIOLOGY INSIGHTS (2021)

Letter Hematology

Signals of Th2 immune response from COVID-19 patients requiring intensive care

Luca Roncati et al.

ANNALS OF HEMATOLOGY (2020)

News Item Multidisciplinary Sciences

THE RACE FOR CORONAVIRUS VACCINES

Ewen Callaway

NATURE (2020)

Editorial Material Biotechnology & Applied Microbiology

The COVID-19 vaccine development landscape

Tung Thanh Le et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Editorial Material Medicine, General & Internal

Developing Covid-19 Vaccines at Pandemic Speed

Nicole Lurie et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pharmacology & Pharmacy

The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation

Jieliang Wang et al.

AAPS PHARMSCITECH (2020)

Article Public, Environmental & Occupational Health

Vaccine Efficacy Needed for a COVID-19 Coronavirus Vaccine to Prevent or Stop an Epidemic as the Sole Intervention

Sarah M. Bartsch et al.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2020)

Review Pharmacology & Pharmacy

A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic

Colin D. Funk et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Immunoinformatic identification of B cell and T cell epitopes in the SARS-CoV-2 proteome

Stephen N. Crooke et al.

SCIENTIFIC REPORTS (2020)

Article Biochemical Research Methods

In silico trial to test COVID-19 candidate vaccines: a case study with UISS platform

Giulia Russo et al.

BMC BIOINFORMATICS (2020)

Review Immunology

Immunological considerations for COVID-19 vaccine strategies

Mangalakumari Jeyanathan et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Biochemical Research Methods

In silico clinical trials: concepts and early adoptions

Francesco Pappalardo et al.

BRIEFINGS IN BIOINFORMATICS (2019)

Review Immunology

Immunoinformatics: In Silico Approaches and Computational Design of a Multi-epitope, Immunogenic Protein

Armina Alagheband Bahrami et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2019)

Review Virology

From SARS to MERS, Thrusting Coronaviruses into the Spotlight

Zhiqi Song et al.

VIRUSES-BASEL (2019)

Review Immunology

New Vaccine Technologies to Combat Outbreak Situations

Susanne Rauch et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Microbiology

Viral-Induced Enhanced Disease Illness

Maria K. Smatti et al.

FRONTIERS IN MICROBIOLOGY (2018)

Article Public, Environmental & Occupational Health

Estimating the cost of vaccine development against epidemic infectious diseases: a cost minimisation study

Dimitrios Gouglas et al.

LANCET GLOBAL HEALTH (2018)

Article Biochemical Research Methods

A computational model to predict the immune system activation by citrus-derived vaccine adjuvants

Francesco Pappalardo et al.

BIOINFORMATICS (2016)

Review Immunology

Cancer immunoprevention

Olivera J. Finn et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

Review Microbiology

SARS and MERS: recent insights into emerging coronaviruses

Emmie de Wit et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Article Biotechnology & Applied Microbiology

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

Anurodh Shankar Agrawal et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)

Review Pharmacology & Pharmacy

Computational modelling approaches to vaccinology

Francesco Pappalardo et al.

PHARMACOLOGICAL RESEARCH (2015)

Review Medicine, Research & Experimental

Vaccines for the 21st century

Isabel Delany et al.

EMBO MOLECULAR MEDICINE (2014)

Review Immunology

Developments in Viral Vector-Based Vaccines

Takehiro Ura et al.

VACCINES (2014)

Review Cardiac & Cardiovascular Systems

Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology

Annamaria Carusi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

Review Biotechnology & Applied Microbiology

Vaccine protocols optimization: In silico experiences

Francesco Pappalardo et al.

BIOTECHNOLOGY ADVANCES (2010)

Review Pharmacology & Pharmacy

Prediction of MHC-Peptide Binding: A Systematic and Comprehensive Overview

Esther M. Lafuente et al.

CURRENT PHARMACEUTICAL DESIGN (2009)