Journal
TRENDS IN MOLECULAR MEDICINE
Volume 27, Issue 7, Pages 624-626Publisher
CELL PRESS
DOI: 10.1016/j.molmed.2021.03.007
Keywords
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Funding
- National Natural Science Foundation of China [81720108032, 81930109, 81973556]
- Project for Major New Drug Innovation and Development [2018ZX09711001-002-003]
- Sanming Project of Medicine in Shenzhen [SZSM201801060]
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Host-microbiota interactions are essential for various physiological events, and harnessing the sensory machinery mediated by nuclear receptors could offer an innovative strategy for drug discovery targeted towards gut microbiota.
Host-microbiota interactions are vital for diverse pathophysiological events and may be targeted for innovative therapeutics. Nuclear receptors (NRs) are versatile host sensors of microbial signals that co-ordinate diverse environmental cues with local and remote adaptions. Harnessing NR-mediated sensory machinery could provide an alternative lynchpin for gut microbiota-oriented drug discovery strategy.
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