Journal
TRENDS IN MICROBIOLOGY
Volume 29, Issue 12, Pages 1083-1094Publisher
CELL PRESS
DOI: 10.1016/j.tim.2021.03.012
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Funding
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
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Recent studies utilizing experimental systems biology techniques to explore interactions in simplified model microbial communities have identified novel interactions and described underlying genetic and molecular mechanisms. Integration of these and targeted methods provides comprehensive insights into species interactions in microbial communities.
Interactions between microorganisms in multispecies communities are thought to have substantial consequences for the community. Identifying the molecules and genetic pathways that contribute to such interplay is thus crucial to understand as well as modulate community dynamics. Here I focus on recent studies that utilize experimental systems biology techniques to study these phenomena in simplified model microbial communities. These unbiased biochemical and genomic approaches have identified novel interactions and described the underlying genetic and molecular mechanisms. I discuss the insights provided by these studies, describe innovative strategies used to investigate less tractable organisms and environments, and highlight the utility of integrating these and more targeted methods to comprehensively characterize interactions between species in microbial communities.
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