Journal
TRENDS IN MICROBIOLOGY
Volume 29, Issue 11, Pages 1024-1033Publisher
CELL PRESS
DOI: 10.1016/j.tim.2021.03.009
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Funding
- National Institutes of Health [GM107629, AI132818, AI087946]
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The bacterial flagellar motor is a rotary machine that can rapidly switch between counterclockwise and clockwise rotational directions to control bacterial cell migration behavior. Recent high-resolution structural studies have revealed detailed interactions of the components in both rotational senses, providing insight into the molecular mechanisms underlying flagellar rotation and switching.
The bacterial flagellar motor, a remarkable rotary machine, can rapidly switch between counterclockwise (CCW) and clockwise (CW) rotational directions to control the migration behavior of the bacterial cell. The flagellar motor consists of a bidirectional spinning rotor surrounded by torque-generating stator units. Recent high-resolution in vitro and in situ structural studies have revealed stunning details of the individual components of the flagellar motor and their interactions in both the CCW and CW senses. In this review, we discuss these structures and their implications for understanding the molecular mechanisms underlying flagellar rotation and switching.
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