Journal
TRENDS IN CELL BIOLOGY
Volume 31, Issue 8, Pages 686-701Publisher
CELL PRESS
DOI: 10.1016/j.tcb.2021.04.002
Keywords
-
Categories
Funding
- European Research Council [ERC-StG 311565]
- Dutch Cancer Society [KWF 10999/2017-1]
Ask authors/readers for more resources
REV7, also known as MAD2L2, is a versatile protein that interacts with various proteins to form different complexes, impacting a wide range of cellular processes. It plays important roles in translesion synthesis and mitotic progression, as well as being a central component in the shieldin complex involved in DNA double strand break repair.
The HORMA domain protein REV7, also known as MAD2L2, interacts with a variety of proteins and thereby contributes to the establishment of different complexes. With doing so, REV7 impacts a diverse range of cellular processes and gained increasing interest as more of its activities became uncovered. REV7 has important roles in translesion synthesis and mitotic progression, and acts as a central component in the recently discovered shieldin complex that operates in DNA double strand break repair. Here we discuss the roles of REV7 in its various complexes, focusing on its activity in genome integrity maintenance. Moreover, we will describe current insights on REV7 structural features that allow it to be such a versatile protein.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available