Journal
TRENDS IN BIOTECHNOLOGY
Volume 39, Issue 11, Pages 1221-1235Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2021.03.009
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Funding
- ARC Centre of Excellence in Convergent BioNano Science and Technology
- National Health and Medical Research Council [GNT1197173, GNT1174971]
- Matthew Flinders Fellowship from Flinders University
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This article discusses the trend of introducing bioengineered in vitro models in recent years due to a lack of appropriate human placenta models, with a focus on the maternal-foetal barrier. It emphasizes the importance of cell type, mechanical forces, and culture microenvironment towards the use of physiologically relevant models.
Driven by a lack of appropriate human placenta models, recent years have seen the introduction of bioengineered in vitro models to better understand placental health and disease. Thus far, the focus has been on the maternal-foetal barrier. However, there are many other physiologically and pathologically significant aspects of the placenta that would benefit from state-of-the-art bioengineered models, in particular, integrating advanced culture systems with contemporary biological concepts such as organoids. This critical review defines and discusses the key parameters required for the development of physiologically relevant in vitro models of the placenta. Specifically, it highlights the importance of cell type, mechanical forces, and culture microenvironment towards the use of physiologically relevant models to improve the understanding of human placental function and dysfunction.
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