Challenges and innovations in chiral drugs in an environmental and bioanalysis perspective

The boundary of the chiral environmental, forensic and bioanalysis has been critically presented in this review. Important advances regarding chiral screening technology and their impact on method devel-opment and applications have been pointed out. The complexity of merging high efficiency enantiose-lectivity separation with the selected sample matrix and the intended goal of the analysis is not a trivial task and in many cases the application of the method is the main novelty. Regardless of the complexity of new applications on chiral separation analysis, the trend is towards reaching higher levels of detectability and lower sample volumes. An assorted variety of methods applications in environmental and bio-analysis, including demand in forensic analysis is herein concisely discussed. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

This review critically presents the boundaries of chiral environmental, forensic, and bioanalysis, highlighting important advances in chiral screening technology and their impact on method development and applications. The complexity of merging high efficiency enantioselectivity separation with the selected sample matrix and analysis goal is emphasized, with a trend towards higher detectability and lower sample volumes in new applications. An assortment of method applications in environmental and bioanalysis, along with the demand in forensic analysis, is concisely discussed.