4.5 Article

Developmental toxicity testing of the fume condensate extracts of bitumen and oxidized asphalt in a series of in vitro alternative assays

Related references

Note: Only part of the references are listed.
Article Reproductive Biology

Prenatal developmental toxicity studies on fumes from bitumen in the rat

Peter J. Boogaard et al.

Summary: The study on prenatal developmental toxicity of bitumen fume in rats showed dose-related effects on body weight and organs, with a maternal NOAEL of 52 mg/m(3). High-dose exposure resulted in treatment-related effects on body weight, food consumption, lung weights, and histopathological changes in lungs and larynx. However, fetal anomalies were not induced even at the highest concentration of 482 mg/m(3).

REPRODUCTIVE TOXICOLOGY (2021)

Article Reproductive Biology

Prenatal developmental toxicity studies on fumes from oxidised asphalt (OA) in the rat

Peter J. Boogaard et al.

Summary: Rats exposed to fumes of oxidised asphalt did not show prenatal developmental toxicity, however, high-dose exposure resulted in effects on maternal body weight gain, food consumption, lung weights, and histopathological changes in lungs and the upper respiratory tract.

REPRODUCTIVE TOXICOLOGY (2021)

Review Toxicology

Toxicological and ecotoxicological properties of gas-to-liquid (GTL) products. 1. Mammalian toxicology

Peter J. Boogaard et al.

CRITICAL REVIEWS IN TOXICOLOGY (2017)

Review Biochemistry & Molecular Biology

The human Ah receptor: hints from dioxin toxicities to deregulated target genes and physiological functions

Karl Walter Bock

BIOLOGICAL CHEMISTRY (2013)

Article Medicine, Legal

The relationship between developmental toxicity and aromatic-ring class profile of high-boiling petroleum substances

F. Jay Murray et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish

Britton C. Goodale et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Timing is everything: Consequences of transient and sustained AhR activity

Kristen A. Mitchell et al.

BIOCHEMICAL PHARMACOLOGY (2009)

Article Environmental Sciences

SPECIFIC IN VITRO TOXICITY OF CRUDE AND REFINED PETROLEUM PRODUCTS. 1. ARYL HYDROCARBON RECEPTOR-MEDIATED RESPONSES

Cozmina M. Vrabie et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2009)

Article Environmental Sciences

24 months inhalation carcinogenicity study of bitumen fumes in Wistar (WU) rats

Rainer Fuhst et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE (2007)

Article Pharmacology & Pharmacy

Sustained aryl hydrocarbon receptor activity attenuates liver regeneration

Kristen A. Mitchell et al.

MOLECULAR PHARMACOLOGY (2006)

Review Pharmacology & Pharmacy

Ah receptor signals cross-talk with multiple developmental pathways

A Puga et al.

BIOCHEMICAL PHARMACOLOGY (2005)

Article Pharmacology & Pharmacy

Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons

JP Incardona et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)

Article Biochemistry & Molecular Biology

Role of the aryl hydrocarbon receptor in cell cycle regulation

A Puga et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2002)

Article Biotechnology & Applied Microbiology

Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay

M Machala et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2001)

Article Chemistry, Analytical

Luminescence spectroscopy as a screening tool for the potential carcinogenicity of asphalt fumes

LV Osborn et al.

JOURNAL OF ENVIRONMENTAL MONITORING (2001)