Intermediate-Dose versus Standard-Dose Prophylactic Anticoagulation in Patients with COVID-19 Admitted to the Intensive Care Unit: 90-Day Results from the INSPIRATION Randomized Trial

Article Medicine, General & Internal

Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19

Hanny Al-Samkari et al.

Summary: Among 3239 critically ill adults with COVID-19, 6.3% developed VTE and 2.8% experienced major bleeding. Early therapeutic anticoagulation did not impact survival in this cohort study.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Association of Body Mass Index and Age With Morbidity and Mortality in Patients Hospitalized With COVID-19 Results From the American Heart Association COVID-19 Cardiovascular Disease Registry

Nicholas S. Hendren et al.

Summary: This study found that obese patients are more likely to be hospitalized with COVID-19, and are at higher risk of in-hospital death or mechanical ventilation, particularly if young (age <= 50 years). Additionally, obese patients are also at higher risk for venous thromboembolism and dialysis. These observations support clear public health messaging and rigorous adherence to COVID-19 prevention strategies in all obese individuals regardless of age.

CIRCULATION (2021)

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Article Public, Environmental & Occupational Health

Surviving COVID-19 in Bergamo province: a post-acute outpatient re-evaluation

Serena Venturelli et al.

Summary: Bergamo province implemented a multidisciplinary follow-up program for COVID-19 patients, with over half of the initial group still experiencing symptoms such as fatigue, dyspnoea, and post-traumatic psychological consequences; additionally, 19% showed impaired lung function, and 17% had elevated D-dimer levels suggesting possible pulmonary embolism.

EPIDEMIOLOGY AND INFECTION (2021)

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Review Critical Care Medicine

Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019 A Systematic Review and Meta-analysis

David Jimenez et al.

Summary: The pooled incidence of VTE and bleeding among hospitalized patients with COVID-19 was 17.0% and 7.8% respectively. Factors such as routine screening, critical illness, inclusion of distal DVT and subsegmental PE, and prospective studies were associated with higher rates of VTE. The incidence of bleeding events was sensitive to escalated doses of anticoagulants and the nature of data collection.

CHEST (2021)

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Article Hematology

Incidence of symptomatic venous thromboembolism following hospitalization for coronavirus disease 2019: Prospective results from a multi-center study

Farid Rashidi et al.

Summary: The rate of symptomatic VTE in COVID-19 patients after hospital discharge is not high, suggesting that routine extended thromboprophylaxis may not provide a net clinical benefit. Randomized trials are needed to further investigate this conclusion.

THROMBOSIS RESEARCH (2021)

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Article Hematology

American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19

Adam Cuker et al.

Summary: The American Society of Hematology provided two conditional recommendations for anticoagulation in COVID-19-related critical illness and acute illness, emphasizing the low certainty in the evidence and the importance of future high-quality randomized controlled trials for validation.

BLOOD ADVANCES (2021)

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Article Medicine, General & Internal

Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit The INSPIRATION Randomized Clinical Trial

Parham Sadeghipour et al.

Summary: This study compared the effect of intermediate-dose and standard prophylactic anticoagulation on a composite outcome among COVID-19 patients admitted to the ICU. The results showed no significant difference between the two groups in terms of thrombotic events, ECMO therapy, or mortality within 30 days. The study does not recommend routine use of intermediate-dose prophylactic anticoagulation in unselected ICU patients with COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19

Azita H. Talasaz et al.

Summary: COVID-19 induces endothelial injury and thrombosis, but the optimal thromboprophylactic regimens are still unknown across the spectrum of illness severity. Ongoing randomized controlled trials are assessing various antithrombotic agents, doses, and durations, presenting opportunities and challenges for the clinical trial enterprise.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

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Letter Medicine, General & Internal

Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California

Nareg H. Roubinian et al.

JAMA INTERNAL MEDICINE (2021)

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Article Hematology

Pulmonary Embolism Does Not Have an Unusually High Incidence Among Hospitalized COVID19 Patients

Nicolas Gallastegui et al.

Summary: COVID19-induced acute respiratory illnesses are on the rise globally. Previous assumptions of high PE incidence in hospitalized COVID19 patients have been debunked by a systematic review, which found lower PE rates, particularly in larger studies. The incidence of microthrombosis in COVID19 patients remains unknown.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

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Review Hematology