Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 785, Issue -, Pages 50-58Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2015.03.098
Keywords
Neutrophil; Inflammation; Cell function; Short chain fatty acids; Saturated fatty acid; Unsaturared fatty acid
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/10653-9, 13/06810-4]
- Fundacao de Desenvolvimento da Unicamp (Funcamp)
- FAPESP [12/15774-9]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/15774-9, 13/06810-4, 12/10653-9] Funding Source: FAPESP
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Neutrophils are well-known to act in the destruction of invading microorganisms. They have also been implicated in the activation of other immune cells including B- and T-lymphocytes and in the resolution of inflammation and tissue regeneration. Neutrophils are produced in the bone marrow and released into the circulation from where they migrate to tissues to perform their effector functions. Neutrophils are in constant contact with fatty acids that can modulate their function, activation and fate (survival or cell death) through different mechanisms. In this review, the effects of fatty acids pertaining to five classes, namely, long-chain saturated fatty acids (LCSFAs), short-chain fatty acids (SCFAs), and omega-3 (n-3), omega-6 (n-6) and omega-9 (n-9) unsaturated fatty acids, on neutrophils and the relevance of these effects for disease development are discussed. (C) 2015 Elsevier B.V. All rights reserved.
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