Journal
TETRAHEDRON
Volume 83, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2021.131980
Keywords
Multicomponent reactions; Furanoflavones; Meldrum's acid; Arylglyoxals; Flavones
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An efficient one-pot method was developed for the synthesis of previously unknown furanoflavone derivatives, based on a telescoped multicomponent reaction. The synthesis features regiospecific formation of a distinctive core structure. The advantages include mild conditions, atom economy, and easy workup procedure, avoiding the need for chromatographic purifications.
An efficient one-pot method for the synthesis of previously unknown furanoflavone derivatives was elaborated. The suggested approach based on telescoped multicomponent reaction of various flavones, arylglyoxals and Meldrum's acid. A distinctive feature of studied condensation is regiospecific formation of 4H-furo[2,3-h]chromene core. The advantages of this synthesis are mild conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structure of one of furanoflavone derivatives was determined by X-ray diffraction. (C) 2021 Elsevier Ltd. All rights reserved.
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