Journal
TETRAHEDRON
Volume 91, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2021.132195
Keywords
Synthesis method; Solid-phase organic synthesis; Reducing agents; Borohydride
Categories
Funding
- National Council for Science and Technology of Mexico (CONACYT-Mexico) [418361]
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An efficient methodology for the synthesis of neutral reducing agents supported on Merrifield resin has been developed, leading to the successful generation of a library of 40 agents with high yields and reusability potential.
An efficient methodology for the synthesis of neutral reducing agents supported on Merrifield resin has been developed. The process was carried out under mild conditions, varying the linker length, the bidentate chelating amine and the alkali metal tetrahydroborate. Fluorescence and infrared spectroscopies and thermogravimetric analysis were used for monitoring the chemical modifications. The developed methodology proved to be successful in obtaining a library of 40 neutral reducing agents supported on Merrifield resin in high yields (90-95%), with the potential to reduce carbonyl compounds and to be reusable. (C) 2021 Elsevier Ltd. All rights reserved.
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