An overview on molecular imprinted polymers combined with surface-enhanced Raman spectroscopy chemical sensors toward analytical applications

Surface-enhanced Raman spectroscopy (SERS) is a powerful and high-speed detection technology. It provides information on molecular fingerprint recognition with ultrahigh sensitive detection. However, it shows poor anti-interference capacity against complex matrices. Molecularly imprinted polymers (MIPs) can achieve specific recognition of targets from complex matrices. Through introducing the MIP separation system, the MIP-SERS chemical sensor can effectively overcome the limitation of complex matrix interference, and further improve the stability of sensors for detection. Herein, the materials and structures of integrated MIP-SERS sensors are systematically reviewed, and its application as a sensor for chemical detection of hazardous substances in environmental and food samples has been addressed as well. To broaden the prospects of application, we have discussed the current challenges and future perspectives that would accelerate the development of versatile MIP-SERS chemical sensors.

Automated summary

SERS technology offers ultrahigh sensitivity but is vulnerable to interference in complex matrices; by enhancing specific target recognition capabilities, MIPs can effectively address the issue of interference in complex matrices when combined with SERS technology; integrated MIP-SERS sensors hold promise for chemical detection of hazardous substances in environmental and food samples.