Journal
SYNLETT
Volume 33, Issue 2, Pages 109-115Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1499-8679
Keywords
amino acids; decarboxylation; photoredox catalysis; radicals
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Funding
- Svenska Forskningsradet Formas [201901269]
- Vetenskapsradet (Swedish Research Council) [202004764]
- Magnus Bergvalls Stiftelse (Magnus Bergvall foundation)
- Kungliga Tekniska Hogskolan (KTH Royal Institute of Technology)
- Olle Engkvist Foundation
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Recent progress has been made in accessing unnatural alpha-amino acids through photoredox-mediated synthetic methods with a focus on various decarboxylative radical-based strategies.
Recently, development of general synthetic routes to unnatural alpha-amino acids has gained significant momentum, driven by the high demand for such building blocks in fundamental research within molecular and structural biology, as well as for development of new pharmaceuticals. Herein, we highlight the recent progress in employing photoredox-mediated synthetic methods for accessing unnatural alpha-amino acids with a focus on various decarboxylative radical-based strategies.
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