Syntheses of Heterocycle-2,3-Fused Indoline and Azaindoline Derivatives

We describe a practical method for synthesizing heterocycle-2,3-fused indoline or azaindoline derivatives through haloetherification and cyclization. We applied this method in syntheses of six- to eight-membered heterocycle-2,3-fused indoline and azaindoline derivatives. These derivatives, which contain sp(3)-hybridized carbons, might be useful as new scaffolds in medicinal chemistry.

Automated summary

A practical method for synthesizing heterocycle-2,3-fused indoline or azaindoline derivatives through haloetherification and cyclization was described and applied in syntheses of six- to eight-membered heterocycle-2,3-fused indoline and azaindoline derivatives, which contain sp(3)-hybridized carbons and might serve as new scaffolds in medicinal chemistry.