4.4 Article

Copper-Catalyzed Synthesis of β- and δ-Carbolines by Double N-Arylation of Primary Amines

Journal

SYNLETT
Volume 32, Issue 10, Pages 1004-1008

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1720461

Keywords

catalysis; heterocycles; cross-coupling; cyclizations; copper

Funding

  1. Vietnam National Foundation for Science and Technology Development (NAFOSTED) [104.01-2020.35]

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Two efficient methods for synthesizing beta- and delta-carbolines from 3,4-dibromopyridine are reported, involving Cu-catalyzed double C-N coupling reactions and subsequent Pd-catalyzed C-N coupling with amines.
Two efficient and practical approaches are reported for the synthesis of beta- and delta-carbolines from 3,4-dibromopyridine. The synthesis is based on site-selective Cu-catalyzed double C-N coupling reactions and subsequent annulations by twofold Pd-catalyzed C-N coupling with amines.

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