Concise Total Synthesis of (+)-Aphanorphine

A concise total synthesis of (+)-aphanorphine is described. The key features of the strategy include a Pd-catalyzed intermolecular trimethylenemethane [3+2]-cycloaddition to form ring C and a Co-catalyzed radical cyclization through a hydrogen-atom transfer to close ring B. The synthesis was completed in six steps.

Automated summary

A concise total synthesis of (+)-aphanorphine was achieved in six steps, utilizing key features such as Pd-catalyzed intermolecular trimethylenemethane [3+2]-cycloaddition for forming ring C and Co-catalyzed radical cyclization through hydrogen-atom transfer to close ring B.