Journal
SYNLETT
Volume 33, Issue 2, Pages 155-160Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1471-9080
Keywords
fluorene; fluorenone; multicomponent reactions; Ugi reaction; isocyanofluorene; spiro compounds
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Funding
- Hellenic Foundation for Research and Innovation (H.F.R.I.) under the '2nd Call for H.F.R.I. Research Projects to support Post-Doctoral Researchers' [0911]
- China Scholarship Council
- European Lead Factory (IMI) [115489]
- Qatar National Research Foundation [NPRP6-065-3-012]
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie [ITN 'Accelerated Early stage drug dIScovery'] [675555]
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie [ALERT] [665250]
- European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie [PROMINENT] [754425]
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The synthesis of fluorene and fluorenone through isocyanide-based multicomponent reactions (IMCRs) has led to the discovery of 23 unprecedented adducts, demonstrating the potential for further utilization in diverse and complex derivatives.
Fluorene and fluorenone are privileged structures with extensive utility in both materials science and drug discovery. Here, we describe syntheses of those moieties through isocyanide-based multicomponent reactions (IMCRs) and the incorporation of the products in diverse and complex derivatives that can be further utilized. We performed six different IMCRs, based on the dual functionality of 9-isocyano-9H-fluorene, and we describe 23 unprecedented adducts.
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