Identifying classes of the pain, fatigue, and depression symptom cluster in long-term prostate cancer survivors-results from the multi-regional Prostate Cancer Survivorship Study in Switzerland (PROCAS)

Purpose Aside from urological and sexual problems, long-term (>= 5 years after initial diagnosis) prostate cancer (PC) survivors might suffer from pain, fatigue, and depression. These concurrent symptoms can form a cluster. In this study, we aimed to investigate classes of this symptom cluster in long-term PC survivors, to classify PC survivors accordingly, and to explore associations between classes of this cluster and health-related quality of life (HRQoL). Methods Six hundred fifty-three stage T1-T3N0M0 survivors were identified from the Prostate Cancer Survivorship in Switzerland (PROCAS) study. Fatigue was assessed with the EORTC QLQ-FA12, depressive symptoms with the MHI-5, and pain with the EORTC QLQ-C30 questionnaire. Latent class analysis was used to derive cluster classes. Factors associated with the derived classes were determined using multinomial logistic regression analysis. Results Three classes were identified: class 1 (61.4%) - low pain, low physical and emotional fatigue, moderate depressive symptoms; class 2 (15.1%) - low physical fatigue and pain, moderate emotional fatigue, high depressive symptoms; class 3 (23.5%) - high scores for all symptoms. Survivors in classes 2 and 3 were more likely to be physically inactive, report a history of depression or some other specific comorbidity, be treated with radiation therapy, and have worse HRQoL outcomes compared to class 1. Conclusion Three distinct classes of the pain, fatigue, and depression cluster were identified, which are associated with treatment, comorbidities, lifestyle factors, and HRQoL outcomes. Improving classification of PC survivors according to severity of multiple symptoms could assist in developing interventions tailored to survivors' needs.

Automated summary

Three distinct classes of the pain, fatigue, and depression cluster were identified among long-term prostate cancer survivors, with class 1 having low pain, low physical and emotional fatigue, and moderate depressive symptoms; class 2 having low physical fatigue and pain, moderate emotional fatigue, and high depressive symptoms; and class 3 having high scores for all symptoms. Survivors in class 2 and 3 were more likely to have physical inactivity, history of depression or specific comorbidities, receive radiation therapy, and have worse health-related quality of life outcomes.