Journal
STROKE
Volume 52, Issue 7, Pages 2456-2464Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.120.033431
Keywords
central nervous system; connective tissue; fibroblasts; glymphatic system; meninges; stroke
Categories
Funding
- National Institutes of Health [R01HL146574, R21AG064422]
- American Heart Association [20PRE35210605]
Ask authors/readers for more resources
This review discusses the anatomical location and molecular markers of fibroblast-like cells in the CNS, their functions in CNS development and neurological disorders, and current challenges and future directions in the field of research on CNS fibroblast-like cells.
Fibroblasts are the most common cell type of connective tissues. In the central nervous system (CNS), fibroblast-like cells are mainly located in the meninges and perivascular Virchow-Robin space. The origins of these fibroblast-like cells and their functions in both CNS development and pathological conditions remain largely unknown. In this review, we first introduce the anatomic location and molecular markers of CNS fibroblast-like cells. Next, the functions of fibroblast-like cells in CNS development and neurological disorders, including stroke, CNS traumatic injuries, and other neurological diseases, are discussed. Third, current challenges and future directions in the field are summarized. We hope to provide a synthetic review that stimulates future research on CNS fibroblast-like cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available