Central Nervous System Fibroblast-Like Cells in Stroke and Other Neurological Disorders

Fibroblasts are the most common cell type of connective tissues. In the central nervous system (CNS), fibroblast-like cells are mainly located in the meninges and perivascular Virchow-Robin space. The origins of these fibroblast-like cells and their functions in both CNS development and pathological conditions remain largely unknown. In this review, we first introduce the anatomic location and molecular markers of CNS fibroblast-like cells. Next, the functions of fibroblast-like cells in CNS development and neurological disorders, including stroke, CNS traumatic injuries, and other neurological diseases, are discussed. Third, current challenges and future directions in the field are summarized. We hope to provide a synthetic review that stimulates future research on CNS fibroblast-like cells.

Automated summary

This review discusses the anatomical location and molecular markers of fibroblast-like cells in the CNS, their functions in CNS development and neurological disorders, and current challenges and future directions in the field of research on CNS fibroblast-like cells.