Journal
STEM CELL RESEARCH
Volume 53, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scr.2021.102373
Keywords
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Funding
- National Institute on Aging (NIA) [UF1AG032438]
- German Center for Neurodegenerative Diseases (DZNE) [UF1AG032438]
- Raul Carrea Institute for Neurological Research (FLENI) [UF1AG032438]
- Research and Development Grants for Dementia from Japan Agency for Medical Research and Development (AMED)
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI)
- Yulgilbar Alzheimer's Research Program
- DHB Foundation
- Dementia Australia
- Brain Foundation
- National Health and Medical Research Council [1154389]
- University of Melbourne
- National Health and Medical Research Council of Australia [1154389] Funding Source: NHMRC
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The study achieved genome-editing of an existing iPSC line carrying the APP London mutation into an iPSC line with the corrected pathogenic mutation. The resulting isogenic iPSC line retained pluripotent stem cell characteristics, normal karyotype, pluripotency marker expression, and the ability to differentiate into the three germ-layers in vitro.
We report the genome-editing of an existing iPSC line carrying the London mutation in APP (V717I) into an iPSC line in which the pathogenic mutation was corrected. The resulting isogenic iPSC line maintained pluripotent stem cell morphology, a normal karyotype, expression of pluripotency markers and the ability to differentiate into the three germ-layers in vitro.
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