Journal
SMALL
Volume 17, Issue 21, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202007671
Keywords
s‐ nitrosothiol; NO donor; organosilica; cancer therapy
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Funding
- Australian Research Council, Queensland Government
- Australian National Fabrication Facility
- Australian Microscopy and Micro-analysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland
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This study presents the use of tetrasulfide-modified mesoporous organosilica nanoparticles for enhanced intracellular delivery of nitric oxide (NO), showing approximately 10 times higher delivery compared to a commercial NO donor. The tetrasulfide chemistry modulates the intracellular decomposition of SNO, shifting production from ammonia (NH3) to NO in glutathione-rich cancer cells, providing a new strategy to control NO levels in biological systems.
Cellular delivery of nitric oxide (NO) using NO donor moieties such as S-nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH3) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, approximate to 10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH3 to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems.
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