Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 108, Issue -, Pages 83-90Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2016.08.015
Keywords
Dexamethasone; Controlled delivery; Laponite; Corticosteroids; Vitreous humor
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Funding
- Instituto de Salud Carlos III [PI12/02285]
- Diputacion General de Aragon (Ell Group - European Regional Development Funds)
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Laponite clay is able to retain dexamethasone by simple physisorption, presumably accomplished by hydrogen bonding formation and/or complexation with sodium counterions, as shown by solid state NMR. The physisorption can be somehow modulated by changing the solvent in the adsorption process. This simple system is able to deliver dexamethasone in a controlled manner to solutions used as models for vitreous humor. The proven biocompatibility of laponite as well as its transparency in the gel state, together with the simplicity of the preparation method, makes this system suitable for future in vivo tests of ophthalmic treatment. (C) 2016 Elsevier B.V. All rights reserved.
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