Fibrinolysis in Venous Thromboembolism

Fibrinolysis is of paramount importance in maintaining or regaining the patency of veins and pulmonary arteries obstructed by thrombi. Growing experimental and clinical evidence indicates that impaired fibrinolysis mediated by multiple complex mechanisms is involved in venous thromboembolism (VTE). Global plasma fibrin clot lysis markers, especially clot lysis time, have been reported to predict recurrent deep-vein thrombosis and pulmonary embolism. The current overview summarizes available data linking fibrinolysis to VTE and its long-term sequelae.

Automated summary

Fibrinolysis is crucial for maintaining or restoring the patency of veins and pulmonary arteries obstructed by thrombi. Impaired fibrinolysis is implicated in venous thromboembolism (VTE) through complex mechanisms, with markers like clot lysis time predicting recurrent deep-vein thrombosis and pulmonary embolism. This overview summarizes the link between fibrinolysis and VTE, along with its long-term consequences.