Journal
SEMINARS IN CANCER BIOLOGY
Volume 86, Issue -, Pages 1014-1025Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2021.05.012
Keywords
Cancer; Clostridium; Quorum sensing; Salmonella; Tumors
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2020R1A4A2002854]
- Bio & Medical Technology Development Program of the NRF - Korean government (MSIT) [2021M3A9I5023254]
- National Research Foundation of Korea [2021M3A9I5023254] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Bacteria associated with the human body can survive in tumors and produce substances that can kill tumor cells, making them potential anticancer agents.
Bacteria are associated with the human body and colonize the gut, skin, and mucous membranes. These asso-ciations can be either symbiotic or pathogenic. In either case, bacteria derive more benefit from their host. The ability of bacteria to enter and survive within the human body can be exploited for human benefit. They can be used as a vehicle for delivering or producing bioactive molecules, such as toxins and lytic enzymes, and even-tually for killing tumor cells. Clostridium and Salmonella have been shown to infect and survive within the human body, including in tumors. There is a need to develop genetic circuits, which enable bacterial cells to carry out the following activities: (i) escape the human immune system, (ii) invade tumors, (iii) multiply within the tumorous cells, (iv) produce toxins via quorum sensing at low cell densities, and (v) express suicide genes to undergo cell death or cell lysis after the tumor has been lysed. Thus, bacteria have the potential to be exploited as anticancer agents.
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