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FUTURE MEDICINAL CHEMISTRY (2011)
Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development
Eva Chung et al.
IMMUNOLOGIC RESEARCH (2011)
Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
Scott M. Wilhelm et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)
Audrey Carriere et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Mitogen-activated Protein Kinase Kinase 1 (MEK1) Stabilizes MyoD through Direct Phosphorylation at Tyrosine 156 During Myogenic Differentiation
Chulman Jo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Comparative Metabolic Flux Profiling of Melanoma Cell Lines BEYOND THE WARBURG EFFECT
David A. Scott et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
BAD Contributes to RAF-mediated Proliferation and Cooperates with B-RAF-V600E in Cancer Signaling
Lisa Polzien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors
Alexandra E. Gould et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex
Michelle C. Mendoza et al.
MOLECULAR CELL (2011)
Regulation of Primary Response Genes
Trent Fowler et al.
MOLECULAR CELL (2011)
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
Daniela Gaglio et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
Poulikos I. Poulikakos et al.
NATURE (2011)
The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis
Bjoern Buchholz et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2011)
c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation
Gretchen Poortinga et al.
NUCLEIC ACIDS RESEARCH (2011)
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Simon A. Forbes et al.
NUCLEIC ACIDS RESEARCH (2011)
Resistance to MEK Inhibitors: Should We Co-Target Upstream?
Poulikos I. Poulikakos et al.
SCIENCE SIGNALING (2011)
RAF protein-serine/threonine kinases: Structure and regulation
Robert Roskoski
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
The Resorcylic Acid Lactone Hypothemycin Selectively Inhibits the Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase Pathway in Cells
Hidesuke Fukazawa et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2010)
Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo
Kihyun Kim et al.
BRITISH JOURNAL OF HAEMATOLOGY (2010)
Cell Signaling by Receptor Tyrosine Kinases
Mark A. Lemmon et al.
CELL (2010)
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival
Matthias Drosten et al.
EMBO JOURNAL (2010)
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells
Sumin Kang et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of RO5068760, an MEK Inhibitor, in Healthy Volunteers: Assessment of Target Suppression
Lucy Lee et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2010)
Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling
Daniel A. Ritt et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Genetic Demonstration of a Redundant Role of Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Mitogen-Activated Protein Kinases in Promoting Fibroblast Proliferation
Laure Voisin et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Dependence on Phosphoinositide 3-Kinase and RAS-RAF Pathways Drive the Activity of RAF265, a Novel RAF/VEGFR2 Inhibitor, and RAD001 (Everolimus) in Combination
Pierre Mordant et al.
MOLECULAR CANCER THERAPEUTICS (2010)
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos et al.
NATURE (2010)
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
Gideon Bollag et al.
NATURE (2010)
Melanomas acquire resistance toB-RAF(V600E) inhibition by RTK or N-RAS upregulation
Ramin Nazarian et al.
NATURE (2010)
The landscape of somatic copy-number alteration across human cancers
Rameen Beroukhim et al.
NATURE (2010)
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
J. Thomas Parsons et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Linking actin dynamics and gene transcription to drive cellular motile functions
Eric N. Olson et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation
Ryan B. Corcoran et al.
SCIENCE SIGNALING (2010)
Non-hinge-bindingpyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors
Dan M. Berger et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: evidence from an in vitro study
Zhe Zhang et al.
BMC MEDICINE (2009)
Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression
Klaus P. Hoeflich et al.
CANCER RESEARCH (2009)
PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers
Susan Wee et al.
CANCER RESEARCH (2009)
Extracellular Signal-Regulated Kinase Signaling Pathway Regulates Breast Cancer Cell Migration by Maintaining slug Expression
Haoming Chen et al.
CANCER RESEARCH (2009)
RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer
Cory Iverson et al.
CANCER RESEARCH (2009)
Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling
Zain Paroo et al.
CELL (2009)
A Systems Perspective of Ras Signaling in Cancer
Edward C. Stites et al.
CLINICAL CANCER RESEARCH (2009)
Isoform-specific ras functions in development and cancer
Margaret P. Quinlan et al.
FUTURE ONCOLOGY (2009)
Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor
Chunxi Ge et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities
Masaki Goto et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation
Bin Zheng et al.
MOLECULAR CELL (2009)
BrafV600E cooperates with Pten loss to induce metastatic melanoma
David Dankort et al.
NATURE GENETICS (2009)
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal
Federica Catalanotti et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations
K. S. M. Smalley et al.
ONCOGENE (2009)
MEK1 mutations confer resistance to MEK and B-RAF inhibition
Caroline M. Emery et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Corynoxeine Isolated from the Hook of Uncaria rhynchophylla Inhibits Rat Aortic Vascular Smooth Muscle Cell Proliferation through the Blocking of Extracellular Signal Regulated Kinase 1/2 Phosphorylation
Tack-Joong Kim et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase
Andrew K. Takle et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
Stephen D. Barrett et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma
Clara Montagut et al.
CANCER RESEARCH (2008)
ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling
Xin Li et al.
CELLULAR SIGNALLING (2008)
The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival
Warren N. D'Souza et al.
JOURNAL OF IMMUNOLOGY (2008)
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas
Keiran S. M. Smalley et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Multisite phosphorylation regulates Bim stability and apoptotic activity
Anette Hubner et al.
MOLECULAR CELL (2008)
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer-Yen Yang et al.
NATURE CELL BIOLOGY (2008)
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
James Tsai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Selective Raf inhibition in cancer therapy
Vladimir Khazak et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity
Christopher M. Danson et al.
JOURNAL OF CELL SCIENCE (2007)
Hypoxia-inducible factor I and dysregulated c-myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
Jung-Whan Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1
Ki Won Lee et al.
CARCINOGENESIS (2007)
Ras oncogenes and their downstream targets
Krishnaraj Rajalingam et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Raf kinases: Function, regulation and role in human cancer
Deborah T. Leicht et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
Katherine E. Ewings et al.
EMBO JOURNAL (2007)
Role of mitogen-activated protein kinase kinase kinases in signal integration
B. D. Cuevas et al.
ONCOGENE (2007)
MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal
Jian Li et al.
DIFFERENTIATION (2007)
Mek1/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-induced hyperplasia
Florence A. Scholl et al.
DEVELOPMENTAL CELL (2007)
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
Tammie C. Yeh et al.
CLINICAL CANCER RESEARCH (2007)
Role of a cysteine residue in the active site of ERK and the MAPKK family
Makoto Ohori et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
David Dankort et al.
GENES & DEVELOPMENT (2007)
Balancing BMP signaling through integrated inputs into the Smad1 linker
Gopal Sapkota et al.
MOLECULAR CELL (2007)
RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer
P. A. Bignone et al.
ONCOGENE (2007)
Self-renewal of embryonic stem cells by a small molecule
Shuibing Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Ilias Mylonis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis
Vickram Bissonauth et al.
DEVELOPMENT (2006)
Absence of BRAF gene mutation in non-melanoma skin tumors
Massimo Libra et al.
CELL CYCLE (2006)
Regulation and role of Raf-1/B-Raf heterodimerization
LK Rushworth et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
AK Takle et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts
K Mercer et al.
CANCER RESEARCH (2005)
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
M Ohori et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Functional interactions of Raf and MEK with jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic ras signaling pathway
V Adler et al.
BIOCHEMISTRY (2005)
ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis
T Nekrasova et al.
JOURNAL OF IMMUNOLOGY (2005)
ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway:: Implication of p27kip1 in cell response to oxidative stress
YY Hu et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Phosphorylation of Grb10 by mitogen-activated protein kinase:: Identification of Ser150 and Ser476 of human Grb10ζ as major phosphorylation site
P Langlais et al.
BIOCHEMISTRY (2005)
Convergence of cell cycle regulation and growth factor signals on GRASP65
S Yoshimura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death
JW Hong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The gene expression signatures of melanoma progression
C Haqq et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex
TTC Yang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK
CH Chen et al.
EMBO JOURNAL (2005)
Regulation of raf-1 by direct feedback phosphorylation
MK Dougherty et al.
MOLECULAR CELL (2005)
Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
LJ Sundberg-Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation
S Marchetti et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death
PY Yeh et al.
ONCOGENE (2004)
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
E Yeh et al.
NATURE CELL BIOLOGY (2004)
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin a on an important regulatory site
MS Woo et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
DA Tuveson et al.
CANCER CELL (2004)
Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas
K Fransén et al.
CARCINOGENESIS (2004)
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
PTC Wan et al.
CELL (2004)
Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation
A Glading et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
DJ Webb et al.
NATURE CELL BIOLOGY (2004)
ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression
L Le Gallic et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Identification of major ERK-related phosphorylation sites in Gab1
S Lehr et al.
BIOCHEMISTRY (2004)
Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation
M Arnaud et al.
JOURNAL OF IMMUNOLOGY (2004)
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation
G Poortinga et al.
EMBO JOURNAL (2004)
Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin
M Mitsushima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism
PC Chin et al.
JOURNAL OF NEUROCHEMISTRY (2004)
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol
AM Domina et al.
ONCOGENE (2004)
Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT
S Matsuda et al.
EMBO JOURNAL (2004)
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
JF Ohren et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
The RAF proteins take centre stage
C Wellbrock et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration
LO Murphy et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP
N Martinez-Quiles et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic β-cells
F Andreozzi et al.
ENDOCRINOLOGY (2004)
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis
S Ishibe et al.
MOLECULAR CELL (2004)
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
SM Wilhelm et al.
CANCER RESEARCH (2004)
Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo
J Kotzka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Different effects of point mutations within the B-raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase and nuclear factor κB pathway and cellular transformation
T Ikenoue et al.
CANCER RESEARCH (2004)
Involvement of mitogen-activated protein kinase in the cytokineregulated phosphorylation of transcription factor GATA-1
M Towatari et al.
HEMATOLOGY JOURNAL (2004)
Intramolecular dephosphorylation of ERK by MKP3
Y Kim et al.
BIOCHEMISTRY (2003)
Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion
CS Lim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
AJ Aguirre et al.
GENES & DEVELOPMENT (2003)
Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization
N Fujita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
T Brummer et al.
ONCOGENE (2003)
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities
L Nie et al.
EMBO JOURNAL (2003)
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
MK Saba-El-Leil et al.
EMBO REPORTS (2003)
Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation
BAJ Roelen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2
YJ Wu et al.
BIOLOGICAL CHEMISTRY (2003)
A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun
S Morton et al.
EMBO JOURNAL (2003)
PAKI phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
JK Slack-Davis et al.
JOURNAL OF CELL BIOLOGY (2003)
Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf→ MEK→ ERK pathway
MA Woodrow et al.
EXPERIMENTAL CELL RESEARCH (2003)
Mek2 is dispensable for mouse growth and development
LF Bélanger et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
LA Allan et al.
NATURE CELL BIOLOGY (2003)
Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910 - Requirement for ERK activation
I Hunger-Glaser et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Effects of Raf kinase inhibitor protein expression on suppression of prostate cancer metastasis
Z Fu et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2003)
The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB
ZA Felton-Edkins et al.
EMBO JOURNAL (2003)
Mechanisms of regulating the Raf kinase family
H Chong et al.
CELLULAR SIGNALLING (2003)
ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis
AA Brahmbhatt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition
NH Tran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
I Stefanová et al.
NATURE IMMUNOLOGY (2003)
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
J Zhao et al.
MOLECULAR CELL (2003)
Essential role for ERK2 mitogen-activated protein kinase in placental development
N Hatano et al.
GENES TO CELLS (2003)
The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2)
CL Standen et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2003)
Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352
AM Delaney et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells
J Kato-Stankiewicz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Identification of the anti-proliferative protein Tob as a MAPK substrate
M Maekawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation
J Garcia et al.
EMBO JOURNAL (2002)
A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling
SL Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Molecular interpretation of ERK signal duration by immediate early gene products
LO Murphy et al.
NATURE CELL BIOLOGY (2002)
Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38
DM Ouwens et al.
EMBO JOURNAL (2002)
Structural determinants of Ras-Raf interaction analyzed in live cells
T Bondeva et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Mutations of the BRAF gene in human cancer
H Davies et al.
NATURE (2002)
Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases -: Their implication in vascular endothelial growth factor gene transcription
J Milanini-Mongiat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
A Nguyen et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Interactions of β and γENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation
HK Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2
HH Slagsvold et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
KSR is a scaffold required for activation of the ERK/MAPK module
F Roy et al.
GENES & DEVELOPMENT (2002)
An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF
VY Stefanovsky et al.
MOLECULAR CELL (2001)
Mitogen-activated protein kinase phosphorylates and targets inducible cAMP early repressor to ubiquitin-mediated destruction
G Yehia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Spred is a Sprouty-related suppressor of Ras signalling
T Wakioka et al.
NATURE (2001)
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
M Jaumot et al.
ONCOGENE (2001)
Phosphorylation of nuclear phospholipase C β1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I
AM Xu et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
AP-1 in cell proliferation and survival
E Shaulian et al.
ONCOGENE (2001)
MEK kinase activity is not necessary for Raf-1 function
M Hüser et al.
EMBO JOURNAL (2001)
Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
M Mikula et al.
EMBO JOURNAL (2001)
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation
H Habelhah et al.
NATURE CELL BIOLOGY (2001)
Protective role of Raf-1 in Salmonella-induced macrophage apoptosis
V Jesenberger et al.
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