Journal
SEMINARS IN CANCER BIOLOGY
Volume 77, Issue -, Pages 182-193Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2021.03.038
Keywords
Ovarian cancer; Cancer stem cell; Cancer stem cell niche; Tumor microenvironment; Chemotherapy resistance
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Funding
- Japan Society for the promotion of Science [19K09826, 20K09673]
- Grants-in-Aid for Scientific Research [20K09673, 19K09826] Funding Source: KAKEN
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The concept of cancer stem cells has advanced in recent decades, with a focus on their role in tumor heterogeneity and therapeutic resistance. In particular, the interactions between ovarian cancer stem cells and their niches play a key role in chemotherapy resistance in patients with advanced ovarian cancer.
The concept of a cancer stem cell has evolved over the past decades, and research on cancer stem cell biology has entered into a stage of remarkable progress. Cancer stem cells are a major determining factor contributing to the establishment of phenotypic and functional intratumoral heterogeneity in synchronization with their surrounding cancer stem cell niches. They serve as the driving force for cancer initiation, metastasis, and therapeutic resistance in various types of malignancies. In verity, reciprocal interplay between ovarian cancer stem cells and their niches involves a complex but ingeniously orchestrated tumor microenvironment within the intraperitoneal milieu and especially contribute to chemotherapy resistance in patients with advanced ovarian cancer. Herein, we review the principles of our current understanding of the biological features of ovarian cancer stem cells, focusing mainly on the precise mechanisms underlying acquired chemotherapy resistance. Furthermore, we highlight the specific roles of various cancer-associated stromal and immune cells in creating possible cancer stem cell niches that regulate ovarian cancer stemness.
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