Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 83, Issue -, Pages 114-119Publisher
ELSEVIER
DOI: 10.1016/j.ejps.2015.12.017
Keywords
Phthalimides; Phthalazinone derivate; TNF-alpha; Anti-inflammatory effect
Categories
Funding
- PROSUL-CNPq [490600/07]
- University of Buenos Aires UBACyT [20020100100770BA]
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A series of related thalidomide derivatives (2-9) were synthesized by microwave irradiation and evaluated for anti-inflammatory activity. Such activity was assessed in vivo and ex vivo. Compounds 2, 8 and 9 showed the highest levels of inhibition of TNF-alpha production. On rat paw edema and hyperalgesia assays, compound 9, (1,4-phthalazinedione) demonstrated the highest in vivo anti-inflammatory activity. Thus, compound 9 can be considered as a promising compound to be subjected to further modification to obtain new agents for the treatment of inflammatory diseases. (C) 2015 Elsevier B.V. All rights reserved.
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