Journal
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
Volume 58, Issue 2, Pages 289-299Publisher
INST TECNOLOGIA PARANA
DOI: 10.1590/S1516-8913201500305
Keywords
biomaterials; biopolymers; films; membranes; properties and characterization; biomedical applications
Categories
Funding
- Sao Paulo Research Foundation (FAPESP, Brazil)
- Ibero-American Programme for Science, Technology and Development (CYTED, Spain)
- Coordination for the Improvement of Higher Educational Personnel (CAPES, Brazil)
- National Council for Scientific and Technological Development (CNPq, Brazil)
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In this study, the effects of the origin of xanthan used, in combination with chitosan, to prepare films for the treatment of skin lesions were evaluated. The characteristics of the films obtained with xanthan commercially available for the food industry sector and xanthan originated from a fermentation process conducted in a pilot plant were compared. Results showed that the source did not strongly interfere in many of the properties of the films, such as the mechanical properties, cytotoxicity to L929 cells, absorption of simulated body fluid and culture medium, stability in water and saline solution. Hence, even though the properties of biopolymers of different sources might vary, the films prepared with two distinct types of xanthan gum could be considered as potentially safe and similar in terms of relevant characteristics considering the aimed application.
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