Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 94, Issue -, Pages 93-95Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2016.05.027
Keywords
Drug safety; Systems pharmacology; Adverse drug events; Drug development
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Ensuring that drugs are safe and effective is a very high priority for drug development and the US Food and Drug Administration review process. This is especially true today because of faster approval times and smaller clinical trials, especially in oncology and rare diseases. In light of these trends, systems pharmacology is seen as an essential strategy to understand and predict adverse drug events during drug development by analyzing interactions between drugs and multiple targets rather than the traditional one-drug-one-target' approach. This commentary offers an overview of the current trends and challenges of using systems pharmacology to reduce the risks of unintended adverse events. (C) 2016 Elsevier B.V. All rights reserved.
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