Comprehensive review on iodinated X-ray contrast media: Complete fate, occurrence, and formation of disinfection byproducts

Iodinated contrast media (ICM) are drugs which are used in medical examinations for organ imaging purposes. Wastewater treatment plants (WWTPs) have shown incapability to remove ICM, and as a consequence, ICM and their transformation products (IPs) have been detected in environmental waters. ICM show limited biotransformation and low sorption potential. ICM can act as iodine source and can react with commonly used disinfectants such as chlorine in presence of organic matter to yield iodinated disinfection byproducts (IDBPs) which are more cytotoxic and genotoxic than conventionally known disinfection byproducts (DBPs). Even highly efficient advanced treatment systems have failed to completely mineralize ICM, and TPs that are more toxic than parent ICM are produced. This raises issues regarding the efficacy of existing treatment technologies and serious concern over disinfection of ICM containing waters. Realizing this, the current review aims to capture the attention of scientific community on areas of less focus. The review features in depth knowledge regarding complete environmental fate of ICM along with their existing treatment options. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Iodinated contrast media are difficult to remove in wastewater treatment plants and can produce disinfection byproducts that are more cytotoxic and genotoxic. Even highly efficient treatment systems fail to completely mineralize ICM, leading to the production of transformation products that are more toxic than the parent compounds.