Journal
SCIENCE CHINA-CHEMISTRY
Volume 64, Issue 5, Pages 808-816Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-020-9947-4
Keywords
photodynamic therapy; γ -glutamyl transpeptidase; activatable; fluorescence imaging
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Funding
- National Natural Science Foundation of China [21925802, 21878039, 21822804, 21808028, 22022803, 22078046]
- Natural Science Foundation of China-Liaoning Joint Fund [U1908202]
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An activatable photosensitizer Cy-GGT was developed based on the overexpressed GGT enzyme in tumor cells, allowing for precise tumor imaging and efficient inhibition of tumor growth.
Photodynamic therapy (PDT), a light triggered therapeutic mode, has been recognized as an attractive treatment for oncotherapy. The phototoxicity to normal tissues during treatment limited the development of PDT owning to the always on properties of photosensitizers. Activatable photosensitizers are of great importance for improving the selectivity of PDT. Herein, we regarded the overexpressed GGT (gamma-Glutamyl transpeptidase) enzyme in tumor cells as a biomarker and developed an activatable photosensitizer Cy-GGT by decorating a specific recognition moiety of GGT, L-glutamic acid, to a hemicyanine dye based on photosensitizer Cy-NH2. Cy-GGT was in the off state with negligible fluorescence and suppressed singlet oxygen generation, but it could be specifically hydrolyzed to Cy-NH2 in the presence of GGT, accompanied with significant fluorescence recovery and singlet oxygen generation increase under light irradiation. The in vitro and in vivo studies indicated that Cy-GGT was suitable for precise tumor imaging and could work as an efficient photosensitizer for inhibiting tumor growth.
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