Journal
SCIENCE
Volume 372, Issue 6543, Pages 701-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abd5992
Keywords
-
Categories
Funding
- SERB India [CRG/2018/003951]
- UGC-India
Ask authors/readers for more resources
This review summarizes recent elegant discoveries in controlling distal C-H activation through directing group assistance, transient mediators or traceless directors, noncovalent interactions, and catalyst and/or ligand selection.
Transition metal-catalyzed aryl C-H activation is a powerful synthetic tool as it offers step and atom-economical routes to site-selective functionalization. Compared with proximal ortho-C-H activation, distal (meta- and/or para-) C-H activation remains more challenging due to the inaccessibility of these sites in the formation of energetically favorable organometallic pretransition states. Directing the catalyst toward the distal C-H bonds requires judicious template engineering and catalyst design, as well as prudent choice of ligands. This review aims to summarize the recent elegant discoveries exploiting directing group assistance, transient mediators or traceless directors, noncovalent interactions, and catalyst and/or ligand selection to control distal C-H activation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available