Roles of glia-derived extracellular vesicles in central nervous system diseases: an update

Extracellular vesicles (EVs) are a heteroge-neous group of cell-derived membranous vesicles secreted by various cells in the extracellular space. Accumulating evidence shows that EVs regulate cell-to -cell communication and signaling in the pathological processes of various diseases by carrying proteins, lipids, and nucleic acids to recipient cells. Glia-derived EVs act as a double-edged sword in the pathogenesis of central nervous system (CNS) diseases. They may be vectors for the spread of diseases or act as effective clearance sys-tems to protect tissues. In this review, we summarize recent studies on glia-derived EVs with a focus on their relationships with CNS diseases.

Automated summary

Extracellular vesicles (EVs) derived from glial cells play a dual role in the pathogenesis of central nervous system diseases, acting as vectors for disease spread or as protective clearance systems for tissues. By carrying proteins, lipids, and nucleic acids, EVs regulate cell-to-cell communication and signaling in various diseases.