Recent epidemiologic, clinical, and genetic diversity of Toxoplasma gondii infections in non-human primates

Toxoplasma gondii infections are common in humans and animals worldwide. The present review summarizes worldwide information on the prevalence of clinical and subclinical infections, epidemiology, diagnosis, and genetic diversity of T. gondii in non-human primates (NHP) for the past decade. Seroprevalence estimates of T. gondii worldwide were tabulated for each host. Risk factors associated with T. gondii infections are evaluated. New World NHP in captivity are highly susceptible to T. gondii infection with high mortality associated with disseminated toxoplasmosis. T. gondii can be transmitted to NHP in contact with symptomatic NHP. Therefore, precautions should be taken to prevent transmission of T. gondii to humans while handling symptomatic NHP. There were no reports of clinical toxoplasmosis in Old World NHP. Among the different genera of New World NHP, susceptibility to clinical toxoplasmosis varies a great deal; however, factors affecting this susceptibility are not fully understood. Genetic characteristics of T. gondii strains from monkeys is summarized.

Automated summary

Toxoplasma gondii infections are common in humans and animals worldwide, with New World NHP being highly susceptible to infection while Old World NHP show no reports of clinical toxoplasmosis. Susceptibility to clinical toxoplasmosis varies among different genera of New World NHP, with factors affecting this susceptibility not fully understood. Genetic characteristics of T. gondii strains from monkeys are summarized.