Journal
REPRODUCTION
Volume 162, Issue 2, Pages 107-115Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/REP-20-0639
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Funding
- Nature Science Foundation from National Nature Science Foundation of China (NSFC) [31700799, 32070915]
- National Basic Research Program of China [2015CB943300]
- National Key R&D Program of China [2017YFC1001404]
- Training Program for Young Talents of Shanghai Health System [2018YQ07]
- Shanghai Chenguang Program [18CG09]
- Development Fund of Shanghai Talents [2018110]
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The study found that during pregnancy, Eomes plays an important role in the function of CD8(+)T cells, particularly in the case of miscarriage where the number of Eomes(+)dCD8(+)T cells decreases, showing a pro-inflammatory phenotype.
The T-box transcription factor protein eomesodermin (Eomes) is known for both homeostasis and function of effector and memory CD8(+)T cells. However, much less is known about the functional regulation of Eomes on CD8(+)T cells during pregnancy. In the present study, we concluded the higher Eomes expression dCD8(+)T cells during normal early pregnancy. The number of Eomes(+)dCD8(+)T cells decreased in miscarriage. This Eomes(+)dCD8(+)T cell subset also expressed less growth-promoting factors, shifted toward pro-inflammatory phenotype in miscarriage. Primary Trophoblasts and HTR8/SVneo cell line could increase Eomes expression of dCD8(+)T cells from both normal early pregnancy and miscarriage, which might provide a new strategy for therapy to promote maternal-fetal tolerance and prevent pregnancy loss. These findings indicated that Eomes might be promising early warming targets of miscarriage. In addition, this study suggested that the reproductive safety must be a criterion considered in modulating the dose and function of Eomes in CD8(+)T cells to reverse T cell exhaustion.
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