Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2016, Issue 23, Pages 3930-3933Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201600714
Keywords
Acyl chlorides; Hypervalent compounds; Iodine; Appel reaction; Esterification; Amidation
Categories
Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- University of Waterloo
Ask authors/readers for more resources
A novel, in-situ synthesis of dichlorotriphenylphosphorane (Ph3PCl2) is accomplished upon combining PPh3 and the easily prepared hypervalent iodine reagent iodobenzene dichloride (PhICl2). The phosphorane is selectively generated in the presence of carboxylic acid or alcohol residues to rapidly produce acyl chlorides and alkyl chlorides in high yields. Addition of EtOH, PhOH, BnOH, Et2NH or CH2N2 results in the direct synthesis of esters, amides and diazo ketones from carboxylic acids.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available