Association between the promoter haplotype of RTN4 gene and schizophrenia in a Korean population

Previous studies have suggested the involvement of Nogo-A/RTN4 in the pathogenesis of schizophrenia. We investigated an association between the promoter haplotypes of RTN4 comprised of rs1348528-rs1822618rs2241958 and schizophrenia. A significant association between the rare TGA haplotype and schizophrenia was shown (p < 0.0001). Additionally, the promoter activity was profoundly decreased by the TGA haplotype. These results suggested that the TGA haplotype of RTN4 may contribute to the susceptibility of schizophrenia.

Automated summary

Previous studies have suggested that the TGA haplotype of RTN4 is significantly associated with schizophrenia, potentially increasing the susceptibility to the disorder. The rare TGA haplotype was shown to decrease promoter activity, further supporting its role in the pathogenesis of schizophrenia.