Journal
PROGRESS IN NEUROBIOLOGY
Volume 203, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2021.102076
Keywords
Aging; Dementia; M; EEG; Connectivity; Cognition
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Funding
- Albstein Research Foundation
- Fahs-Beck fund for Research and Experimentation
- William and Ella Owens Medical Research Foundation
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Brain activity and communication are complex phenomena, but research on temporal dynamics of neural activity is limited. Current studies focus on MEG and EEG to understand the effects of healthy and pathological aging on neural dynamics, with implications for clinical practice and theory. Insights into these dynamics could lead to new theoretical frameworks and biomarker development for age-related cognitive changes.
Brain activity and communications are complex phenomena that dynamically unfold over time. However, in contrast with the large number of studies reporting neuroanatomical differences in activation relative to young adults, changes of temporal dynamics of neural activity during normal and pathological aging have been grossly understudied and are still poorly known. Here, we synthesize the current state of knowledge from MEG and EEG studies that aimed at specifying the effects of healthy and pathological aging on local and network dynamics, and discuss the clinical and theoretical implications of these findings. We argue that considering the temporal dynamics of brain activations and networks could provide a better understanding of changes associated with healthy aging, and the progression of neurodegenerative disease. Recent research has also begun to shed light on the association of these dynamics with other imaging modalities and with individual differences in cognitive performance. These insights hold great potential for driving new theoretical frameworks and development of biomarkers to aid in identifying and treating age-related cognitive changes.
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