4.3 Review

Roles of ATM and ATR in DNA double strand breaks and replication stress

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Structures and regulations of ATM and ATR, master kinases in genome integrity

Rhys M. Williams et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Structural biology of multicomponent assemblies in DNA double-strand-break repair through non-homologous end joining

Amanda K. Chaplin et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)

Article Multidisciplinary Sciences

CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection

Ilaria Ceppi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Cell Biology

Structural basis of allosteric regulation of Tel1/ATM kinase

Jiyu Xin et al.

CELL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA but no DNA ends

Sarem Hailemariam et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

Tatiana N. Moiseeva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

Challenges to DNA replication in hypoxic conditions

Natalie Ng et al.

FEBS JOURNAL (2018)

Article Cell Biology

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling

Michael Charles Lanz et al.

GENES & DEVELOPMENT (2018)

Article Multidisciplinary Sciences

The shieldin complex mediates 53BP1-dependent DNA repair

Sylvie M. Noordermeer et al.

NATURE (2018)

Article Multidisciplinary Sciences

Regulatory control of DNA end resection by Sae2 phosphorylation

Elda Cannavo et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

Luke A. Yates et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

Cryo-EM structure of human ATR-ATRIP complex

Qinhui Rao et al.

CELL RESEARCH (2018)

Article Biochemistry & Molecular Biology

DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair

Nozomi Tomimatsu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

Ishan Deshpande et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair

Logan R. Myler et al.

MOLECULAR CELL (2017)

Review Biochemistry & Molecular Biology

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

Andrew N. Blackford et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Haijuan Yang et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Dna2 initiates resection at clean DNA double-strand breaks

Sharad C. Paudyal et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

Cryo-EM structure of the DNA-PK holoenzyme

Humayun Sharif et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP

Xuejuan Wang et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

Bancinyane L. Sibanda et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice

Nicole L. Batenburg et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Structures of closed and open conformations of dimeric human ATM

Domagoj Baretic et al.

SCIENCE ADVANCES (2017)

Article Cell Biology

Cryo-EM structure of human DNA-PK holoenzyme

Xiaotong Yin et al.

CELL RESEARCH (2017)

Article Biochemistry & Molecular Biology

Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides

Paulina H. Wanrooij et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response

Yuan-Cho Lee et al.

CURRENT BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

Roopesh Anand et al.

MOLECULAR CELL (2016)

Article Cell Biology

ETAA1 acts at stalled replication forks to maintain genome integrity

Thomas E. Bass et al.

NATURE CELL BIOLOGY (2016)

Article Cell Biology

Activation of the ATR kinase by the RPA-binding protein ETAA1

Peter Haahr et al.

NATURE CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

Francisco Meirelles Bastos de Oliveira et al.

MOLECULAR CELL (2015)

Review Cell Biology

Replication fork reversal in eukaryotes: from dead end to dynamic response

Kai J. Neelsen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Review Pharmacology & Pharmacy

ATM and ATR as therapeutic targets in cancer

Anika Maria Weber et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Editorial Material Cell Biology

Fork reversal, too much of a good thing

Frank B. Couch et al.

CELL CYCLE (2014)

Article Biochemistry & Molecular Biology

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress

Magtouf Gatei et al.

HUMAN MOLECULAR GENETICS (2014)

Article Multidisciplinary Sciences

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

Elda Cannavo et al.

NATURE (2014)

Review Cell Biology

Causes and consequences of replication stress

Michelle K. Zeman et al.

NATURE CELL BIOLOGY (2014)

Article Cell Biology

DNA structure-specific priming of ATR activation by DNA-PKcs

Sophie Vidal-Eychenie et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

Anja M. Duursma et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

Cristina Escribano-Diaz et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

Monica M. Olcina et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

Activation of DSB Processing Requires Phosphorylation of CtIP by ATR

Shaun E. Peterson et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres

Maria Thanasoula et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest

Ronit I. Yarden et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

J. Ross Chapman et al.

MOLECULAR CELL (2012)

Article Cell Biology

Mechanism of p53 stabilization by ATM after DNA damage

Qian Cheng et al.

CELL CYCLE (2010)

Review Biochemistry & Molecular Biology

The DNA Damage Response: Making It Safe to Play with Knives

Alberto Ciccia et al.

MOLECULAR CELL (2010)

Review Biochemistry & Molecular Biology

H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy

Monika Podhorecka et al.

JOURNAL OF NUCLEIC ACIDS (2010)

Article Cell Biology

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

H. Christian Reinhardt et al.

CURRENT OPINION IN CELL BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Emerging common themes in regulation of PIKKs and PI3Ks

Harri Lempiaeinen et al.

EMBO JOURNAL (2009)

Article Biochemistry & Molecular Biology

ATM Activation and Signaling under Hypoxic Conditions

Zuzana Bencokova et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

Vasundhara M. Navadgi-Patil et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Bunsyo Shiotani et al.

MOLECULAR CELL (2009)

Review Biochemistry & Molecular Biology

Mechanism of eukaryotic homologous recombination

Joseph San Filippo et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair

Longchuan Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase

Vasundhara M. Navadgi-Patil et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

CDK targets Sae2 to control DNA-end resection and homologous recombination

Pablo Huertas et al.

NATURE (2008)

Article Multidisciplinary Sciences

Dpb11 activates the Mec1-Ddc2 complex

Daniel A. Mordes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

Navjotsingh Pabla et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

The Rad9-Hus1-Rad1 checkpoint interaction of TopBP1 with ATR

Joon Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Oncology

CDC25 phosphatases in cancer cells: key players? Good targets?

Rose Boutros et al.

NATURE REVIEWS CANCER (2007)

Article Cell Biology

The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1

Sinny Delacroix et al.

GENES & DEVELOPMENT (2007)

Article Multidisciplinary Sciences

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Shuhei Matsuoka et al.

SCIENCE (2007)

Review Cell Biology

ATM activation and DNA damage response

Martin F. Lavin et al.

CELL CYCLE (2007)

Article Biochemistry & Molecular Biology

Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit

Van Leung-Pineda et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

A dynamic model for replication protein A (RPA) function in DNA processing pathways

Ellen Fanning et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biochemistry & Molecular Biology

TopBP1 activates the ATR-ATRIP complex

A Kumagai et al.

Article Biochemistry & Molecular Biology

DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response

RA Freiberg et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Multidisciplinary Sciences

ATRIP associates with replication protein A-coated ssDNA through multiple interactions

Y Namiki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1

ZS You et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

RG Syljuåsen et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Multidisciplinary Sciences

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

JH Lee et al.

SCIENCE (2004)

Review Genetics & Heredity

Dial 9-1-1 for DNA damage: the RaO-Hus1-Rad1 (9-1-1) clamp complex

ER Parrilla-Castellar et al.

DNA REPAIR (2004)

Article Cell Biology

ATR and ATM regulate the timing of DNA replication origin firing

D Shechter et al.

NATURE CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains

M Rodriguez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

MM Vilenchik et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Requirement of the MRN complex for ATM activation by DNA damage

T Uziel et al.

EMBO JOURNAL (2003)

Article Multidisciplinary Sciences

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

L Zou et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

ATR and ATRIP: Partners in checkpoint signaling

D Cortez et al.

SCIENCE (2001)

Article Biochemistry & Molecular Biology

DNA damage-dependent nuclear dynamics of the Mre11 complex

OK Mirzoeva et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Multidisciplinary Sciences

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

S Matsuoka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Multidisciplinary Sciences

Rapid destruction of human Cdc25A in response to DNA damage

N Mailand et al.

SCIENCE (2000)

Article Multidisciplinary Sciences

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

A Hirao et al.

SCIENCE (2000)

Article Biochemistry & Molecular Biology

Repair of endogenous DNA damage

T Lindahl et al.

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (2000)