Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2016, Issue 28, Pages 4824-4833Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201600757
Keywords
Nucleic acids; Cross-coupling; Hydrogen bonds; Carboximides; G-Quadruplexes
Categories
Funding
- Ministero dell'Universita e della Ricerca (MIUR)
- FIRB-Ideas [RBID082ATK_003]
- Italian Association for Cancer Research (AIRC) [IG2013-14708]
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Naphthalene diimides with one or two centrosymmetric arylethynyl moieties capable of synergic donor and acceptor hydrogen bonding exhibit promising binding properties and selectivity towards parallel G-quadruplex (G4) nucleic acids (c-myc, bcl-2 and parallel hTel22). The hydrogen-bonding network involving the phosphate backbone and outside rim of the G-quartet represents an opportunity to exploit G4 selectivity for extended aromatics.
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