4.5 Article

Direct Highly Regioselective Functionalization of Carbohydrates: A Three-Component Reaction Combining the Dissolving and Catalytic Efficiency of Ionic Liquids

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2016, Issue 20, Pages 3339-3343

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201600536

Keywords

Ionic liquids; Organocatalysis; Carbohydrates; NHCs; Regioselectivity

Funding

  1. Swedish Research Council (VR)
  2. Formas
  3. Magnus Bergvalls stiftelse
  4. Chalmers areas of advance nanoscience and nanotechnology

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An unprecedented regioselective functionalization of unprotected polyols has been realized with the use of an ionic liquid NHC precatalyst. The protocol is robust, scalable, and the products can be isolated in good to excellent yields without chromatography. Moreover, the methodology enables successful recycling of the catalyst.

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