Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 20, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2100466118
Keywords
biosensors; pregnancy; vital signs
Categories
Funding
- Bill AMP
- Melinda Gates Foundation [OPP1193311, INV-000787, OPP1192462, INV-001805]
- Save the Children Foundation [999002170]
- NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development [1R41HD10028401]
- Health Resources and Services Administration's Maternal and Child Health Bureau Grand Challenges in Remote Pregnancy Monitoring
- Bill and Melinda Gates Foundation [INV-000787, OPP1193311, INV-001805, OPP1192462] Funding Source: Bill and Melinda Gates Foundation
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The text discusses the importance of monitoring the health and safety of women and newborns during pregnancy, labor, and childbirth, as well as the complexity and high cost of current monitoring systems and the challenges of implementation in low-resource settings. It also introduces an integrated monitoring platform leveraging advanced flexible electronics, wireless connectivity, and compatibility with a wide range of low-cost mobile devices.
Vital signs monitoring is a fundamental component of ensuring the health and safety of women and newborns during pregnancy, labor, and childbirth. This monitoring is often the first step in early detection of pregnancy abnormalities, providing an opportunity for prompt, effective intervention to prevent maternal and neonatal morbidity and mortality. Contemporary pregnancy monitoring systems require numerous devices wired to large base units; at least five separate devices with distinct user interfaces are commonly used to detect uterine contractility, maternal blood oxygenation, temperature, heart rate, blood pressure, and fetal heart rate. Current monitoring technologies are expensive and complex with implementation challenges in low-resource settings where maternal morbidity and mortality is the greatest. We present an integrated monitoring platform leveraging advanced flexible electronics, wireless connectivity, and compatibility with a wide range of low-cost mobile devices. Three flexible, soft, and low-profile sensors offer comprehensive vital signs monitoring for both women and fetuses with time-synchronized operation, including advanced parameters such as continuous cuffless blood pressure, electrohysterography-derived uterine monitoring, and automated body position classification. Successful field trials of pregnant women between 25 and 41 wk of gestation in both highresource settings (n = 91) and low-resource settings (n = 485) demonstrate the system's performance, usability, and safety.
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