Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 18, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2101644118
Keywords
education; aging; cerebral cortex; hippocampus; reserve
Categories
Funding
- European Union-Horizon 2020 Grant: Healthy Minds 0-100 Years: Optimising the Use of European Brain Imaging Cohorts ('Lifebrain') [732592]
- Knut and Alice Wallenberg Foundation
- Norwegian Research Council
- University of Barcelona - Spanish Ministry of Science, Innovation and Universities (European Regional Development Fund) [RTI2018-095181-B-C21]
- Catalan Institution for Research and Advanced Studies Academia 2019 grant award
- Walnuts and Healthy Aging study - California Walnut Commission, Sacramento, CA [NCT01634841]
- European Research Council [677804]
- Cambridge Centre for Ageing and Neuroscience from the Biotechnology and Biological Sciences Research Council
- Medical Research Council Cognition and Brain Sciences Unit
- Center for Lifespan Changes in Brain and Cognition-European Research Council [283634, 725025, 313440]
- German Federal Ministry of Education and Research [16SV5537/16SV5837/16SV5538/16SV5536K/01UW0808/01UW0706/01GL1716A/01GL1716B]
- MRC [G1001354] Funding Source: UKRI
- European Research Council (ERC) [677804, 725025] Funding Source: European Research Council (ERC)
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Despite the modest association between education and cortical volume, higher education does not influence the rates of brain aging. The findings challenge the assumption that education slows down brain aging.
Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging.
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