Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 19, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2018784118
Keywords
participation coefficient; edge density; structural connectivity; functional connectivigy; brain networks
Categories
Funding
- National Institute of Neurological Disorders and Stroke [RO1NS114405, RO1MH122613, P50 MH094258]
- National Institute of Mental Health [R21MH120441]
- National Institute of General Medical Sciences [T32MH1911327]
- Roy J. Carver Charitable Trust
- [1S10OD02502501]
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Lesions disrupting white matter regions with high edge density are more strongly associated with cognitive impairment compared to lesions damaging gray matter regions with high participation coefficient, which helps explain interindividual differences in cognitive outcomes following brain damage.
Hubs are highly connected brain regions important for coordinating processing in brain networks. It is unclear, however, which measures of network hubness are most useful in identifying brain regions critical to human cognition. We tested how closely two measures of hubness-edge density and participation coefficient, derived from white and gray matter, respectively-were associated with general cognitive impairment after brain damage in two large cohorts of patients with focal brain lesions (N = 402 and 102, respectively) using cognitive tests spanning multiple cognitive domains. Lesions disrupting white matter regions with high edge density were associated with cognitive impairment, whereas lesions damaging gray matter regions with high participation coefficient had a weaker, less consistent association with cognitive outcomes. Similar results were observed with six other gray matter hubness measures. This suggests that damage to densely connected white matter regions is more cognitively impairing than similar damage to gray matter hubs, helping to explain interindividual differences in cognitive outcomes after brain damage.
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