Journal
PRENATAL DIAGNOSIS
Volume 41, Issue 5, Pages 620-630Publisher
WILEY
DOI: 10.1002/pd.5927
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft [EXC 2067/1-390729940]
- Novo Nordisk Fonden [NNF15OC001666]
- National Institute of General Medical Sciences [R35GM133747]
- Max-Planck-Gesellschaft
- DNRF Center Grant [DNRF115]
- H2020 European Research Council [724718-ReCAP]
- Leibniz Prize
- National Institute of Child Health and Human Development [R01HD091331]
Ask authors/readers for more resources
The gain or loss of a chromosome, known as aneuploidy, is a major trigger for infertility and pregnancy loss in humans. Recent studies using genomics, cytogenetics, and in silico modeling have shed new light on the potential genetic and cellular factors associated with aneuploidy at different stages of development in human oocytes and embryos.
The gain or loss of a chromosome-or aneuploidy-acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available