4.5 Article

A Corey-Seebach Macrocyclisation Strategy for the Synthesis of Riccardin C and an Unnatural Macrocyclic Bis(bibenzyl) Analogue

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2016, Issue 34, Pages 5738-5746

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201601179

Keywords

Natural products; Total synthesis; Macrocycles; Cyclization; Polycycles

Funding

  1. Umm Al-Qura University, Saudi Arabia
  2. Engineering and Physical Sciences Research Council (EPSRC) [EP/K039466/1]

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A total synthesis of riccardin C has been accomplished using a Corey-Seebach reaction to effect macrocyclisation. The versatility of the strategy has also been demonstrated with a mimetic synthesis of an unnatural bis(bibenzyl) analogue.

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